Regenerative medicine with the low-molecular-weight secretory factors from fetal membrane-derived mesenchymal stem cells

• Project/Area Number: 26501001
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Regenerative medicine
• Research Institution: Hokkaido University
• Principal Investigator: Ohnishi Shunsuke 北海道大学, 医学研究科, 准教授 (10443475)
• Research Collaborator: Masahiro Mori
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 間葉系幹細胞 / 卵膜 / 間葉系 幹細胞

Outline of Final Research Achievements

In this study, I focused on the secretory factors from fetal membrane-derived mesenchymal stem cells, and found that low-molecular-weight fraction of conditioned medium had an anti-inflammatory effect. In addition, I identified a novel secretory lipid that attenuates rats with non-alcoholic steatohepatitis.