| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We made it possible to obtain three-dimensional (3D) tomographic images of the behaviors of multiple radionuclides administered to a living mouse by semiconductor Compton camera GREI with improved quanlitativity, to realize a new metallomics measurement technology that performs imaging analysis of the behaviors of various metal elements and associated biomolecules in living organisms. We applied the technology to the GREI data of Sr-85, Mn-54 and Zn-65 simultaneously administered to a diabetes mellitus model mouse, and succeeded in visualizing the characteristic behavior of Sr-85 in the 3D image clearly, and obtaining the 3D image of Mn-54 that suggested the similar behavior as that of Sr-85. In addition to that, we came up with a new metallomics imaging diagnosis method that takes the GREI images of the radioisotopes of Na and K administered simultaneously.
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