E. coli cells growing under starvation
| Project/Area Number |
26506003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
宇宙生命学
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| Research Institution | University of Tsukuba |
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Principal Investigator |
YING BEIWEN 筑波大学, 生命環境系, 准教授 (90422401)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 増殖 / 実験進化 / 適応 / 栄養枯渇 / 大腸菌 / 翻訳 / 飢餓 / 増殖速度 |
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| Outline of Final Research Achievements |
Expreimental evolution with the E. coli cells in a repeated starvation and resuscitation manner was performed. As a common evolutionary consequence in multiple lines, the evovled cells showed a significant decrease in growth fitness under rich conditions but an improved competence with enhanced affinity to resource under poor conditions. This evolutionary change was accompanied by the fixation of repressed translation and improved transport, owing to the genetic disturbance in regulator and ribosome. Our study provides an experimental evidence of an evolutionary transition in growth economics from time-saving to resource-saving strategies, in adaptation to the slowly and irregularly oscillated environments. It indicated that the resource-saving nature of the evolved cells compensated the deficiency in growth fitness.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Molecular Clock of Neutral Mutations in a Fitness-Increasing Evolutionary Process2015
Author(s)
Kishimoto T, Ying BW, Tsuru S, Iijima L, Suzuki S, Hashimoto T, Oyake A, Kobayashi H, Someya Y, Narisawa D, Yomo T
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Journal Title
PLOS Genetics
Volume: 11(7)
Issue: 7
Pages: 1-18
DOI
NAID
Related Report
Peer Reviewed / Open Access
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