| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Outline of Final Research Achievements |
Expreimental evolution with the E. coli cells in a repeated starvation and resuscitation manner was performed. As a common evolutionary consequence in multiple lines, the evovled cells showed a significant decrease in growth fitness under rich conditions but an improved competence with enhanced affinity to resource under poor conditions. This evolutionary change was accompanied by the fixation of repressed translation and improved transport, owing to the genetic disturbance in regulator and ribosome. Our study provides an experimental evidence of an evolutionary transition in growth economics from time-saving to resource-saving strategies, in adaptation to the slowly and irregularly oscillated environments. It indicated that the resource-saving nature of the evolved cells compensated the deficiency in growth fitness.
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