Natural citrus derived xanthophyll protects bone loss associated with the space microgravity.
Project/Area Number |
26506004
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
宇宙生命学
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Research Institution | Tokyo University of Agriculture and Technology |
Principal Investigator |
HIRATA MICHIKO 東京農工大学, 工学(系)研究科(研究院), 講師 (40544060)
|
Co-Investigator(Kenkyū-buntansha) |
宮浦 千里 東京農工大学, 工学(系)研究科(研究院), 教授 (20138382)
稲田 全規 東京農工大学, 工学(系)研究科(研究院), 准教授 (80401454)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 生物・生体工学 / 宇宙空間 / 骨粗鬆症 / 機能性食品 |
Outline of Final Research Achievements |
In this study, we evaluated the effects of xanthophyll on bone formation and bone resorption, in mouse models for OVX and tail suspension. The most of the functional compound was lutein, a member of the xanthophyll family of carotenoids, suppressed IL-1-induced osteoclast differentiation and bone resorption. The survival of mature osteoclasts was also suppressed by the treatment of lutein in cultures. When lutein was added to the cultures of osteoblasts, lutein enhanced the formation of mineralized bone nodules by elevating BMP2 expression. When OVX or tail suspension mice were orally administered lutein for 4 weeks, the femoral bone mass was enhanced in cancellous bone, as measured by bone mineral density in dual X-ray absorptiometry and micro-CT analyses. Lutein could be a natural compound that promotes bone formation that prevents bone loss associated with the space microgravity.
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Report
(4 results)
Research Products
(71 results)
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[Journal Article] High Potency VEGFRs/MET/FMS Triple Blockade by TAS-115 Concomitantly Suppresses Tumor Progression and Bone Destruction in Tumor-Induced Bone Disease Model with Lung Carcinoma Cells.2016
Author(s)
Fujita H, Gomori A, Fujioka Y, Kataoka Y, Tanaka K,Hashimoto A, Suzuki T, Ito K, Haruma T, Yamamoto-Yokoi H, Harada N, Sakuragi M, Oda N,Matsuo K, Inada M, Yonekura K
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Journal Title
PLOS ONE
Volume: 11(10)
Issue: 10
Pages: e0164830-e0164830
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice.2016
Author(s)
Watanabe K, Hirata M, Tominari T, Matsumoto C, Endo Y, Murphy G, Nagase H, Inada M, Miyaura C
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 478(1)
Pages: 279-285
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The optimal duration of PTH(1-34) infusion is one hour per day to increase bone mass in rats.2016
Author(s)
Shimizu M, Noda H, Joyashiki E, Nakagawa C, Asanuma K, Hayasaka A, Kato M, Nanami M, Inada M, Miyaura C, Tamura T
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Journal Title
Biol Pharm Bull.
Volume: 39(4)
Pages: 625-630
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling that Drives Tumor Growth, Angiogenesis and Metastasis.2015
Author(s)
Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, HirataM, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C
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Journal Title
J. Biol. Chem.
Volume: 290(50)
Pages: 29781-29793
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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