Changes of cardiovascular parameters after postural transition and its regulation according to the development and aging

• Project/Area Number: 26506024
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 宇宙生命学
• Research Institution: Fujita Health University
• Principal Investigator: YAMASAKI Masao 藤田保健衛生大学, 保健学研究科, 教授 (10192395)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
• Keywords: 血圧 / 圧受容器反射 / 体位変換 / Head-up Tilt / 自律神経 / 老化 / 体液シフト / ラット / 循環調節 / 加齢 / 発達 / 姿勢変換 / Head-up tilt / 脳供血 / 動脈圧受容器 / 大動脈神経 / Head-up Tilt / 体血圧 / 模擬微小重力現象 / 圧受容器 / 循環 / 血圧調節

Outline of Final Research Achievements

The intravascular pressure involved with hydrostatic pressure, and its pressure gradient changes and/or differences due to postural transition and posture. These changes lead mainly the arterial baroreceptor reflex (BR) to maintain the Systemic Arterial Pressure: SAP, in other word blood perfusion pressure, contributing the blood supply to brain. The changes of SAP, common carotid arterial flow as blood supply toward head and heat rate (HR) after and during Head-up tilt (HUT) ware examined. These results indicated that the cardiovascular parameters after onset of 30 min HUT fluctuated relatively and the SAP was not maintained well through HUT in un-mature and elder rats compared with mature, suggesting the BR was weaker according to the aging.

Research Products

• [Journal Article] Changes in blood pressure, blood flow towards the head and heart rate during 90?deg head-up tilting for 30?min in anaesthetized male rats (2017)
  • Author(s): Nishimura Hironobu、Yamasaki Masao
  • Journal Title: Experimental Physiology Volume: 103 Issue: 1 Pages: 31-39
  • DOI: 10.1113/ep086543
  • Peer Reviewed
• [Journal Article] Changes in central venous pressure after onset of 90 degrees head-up tilting for 30 min in anesthetized rats (2017)
  • Author(s): Hironobu Nishimura, Masao Yamasaki, Tetsuya Hiraiwa, Chiho Hashimoto, Yuri Sakai, Yusuke Kayama
  • Journal Title: J Physiol. Sci Volume: 67(suppl)
  • Open Access / Acknowledgement Compliant
• [Journal Article] 麻酔下ラット90°Head-up tilting 体位変換時の血圧応答に対する加齢の影響 (2017)
  • Author(s): 西村宗修、平岩徹也、嘉山裕介、酒井有理、橋本千穂、山崎将生
  • Journal Title: 日本生理学雑誌 Volume: 79
  • Acknowledgement Compliant
• [Journal Article] Studies on the cardiovascular system and its regulations under real and simulated microgravity conditions in space and ground-based experiment (2016)
  • Author(s): Masao Yamasaki, Hidefumi Waki, Tsuyoshi Shimizu
  • Journal Title: Abstracts of 11th Asian Microgravity Simposium、2016 Volume: -
  • Acknowledgement Compliant
• [Journal Article] Developmental and age-related characteristics of the changes in cardiovascular parameters during long-term 90 Degrees Head-up Tilting in Anesthetized Rats (2016)
  • Author(s): Hironobu Nishimura, Tetsuya Hiraiwa, Masao Yamasaki, Chiho Hashimoto, Yuri Sakai, Yusuke Kayama
  • Journal Title: Abstracts of 11th Asian Microgravity Simposium、2016 Volume: -
  • Acknowledgement Compliant
• [Journal Article] Developmental characteristics of the changes in the cardiovascular parameters before, during and after 90 degrees head-up tilting in anesthetized rats (2016)
  • Author(s): Chiho Hashimoto, Yamasaki M, Hironobu Nishimura, Tetsuya Hiraiwa, Yuri Sakai, Yusuke Kayama
  • Journal Title: Abstracts of 11th Asian Microgravity Simposium、2016 Volume: -
  • Acknowledgement Compliant
• [Journal Article] The fluctuation of arterial blood pressure after transition to supine posture from upright position in anesthetized rats (2016)
  • Author(s): Tetsuya Hiraiwa, Masao Yamasaki, Hironobu Nishimura, Chiho Hashimoto, Yuri Sakai, Yusuke Kayama
  • Journal Title: Abstracts of 11th Asian Microgravity Simposium、2016 Volume: -
  • Acknowledgement Compliant
• [Journal Article] Baroreflex response to blood pressure change due to postural transitions in aging rats: 90 degrees head-up tilt experiment (2016)
  • Author(s): Masao Yamasaki, Hironobu Nishimura, Tetsuya Hiraiwa
  • Journal Title: J gravtational Physiol:Program and Abstract book Volume: 37
  • Acknowledgement Compliant
• [Journal Article] 東北宇宙生命科学会（Tohoku Society for space sciences,TSSS) (2016)
  • Author(s): 吉岡 利忠、清水 強、山崎 将生
  • Journal Title: 宇宙航空環境医学 Volume: 53（1） Pages: 19-21
  • Open Access
• [Journal Article] Structural, Functional and Developmental Characteristics of Aortic Baroreceptor reflex :Review on Baroreflex Afferent and Its Reflex Mechanisms under Several Environmental Conditions in Rats and Rabbits (2016)
  • Author(s): Masao Yamasaki, Tsuyoshi Shimizu.
  • Journal Title: THE CHINESE JOURNAL OF PHYSIOLOGY (ISSN 0304-4920) Volume: in Press
  • Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Blood pressure is not well maintained during 90 degrees head-up tilt for 30 min in anesthetized aging rats (2016)
  • Author(s): Hironobu Nishimura, Masao Yamasaki, Tetsuya Hiraiwa,Natsuki, Yasuhiro Ito.
  • Journal Title: J Physiol Science Volume: 66(suppl)
  • Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Changes of cardiovascular parameters after 90 degrees head-up tilt in anesthetized rats (2016)
  • Author(s): Tetsuya Hiraiwa, Hironobu Nishimura, Masao Yamasaki.
  • Journal Title: J Physiol Science Volume: 66(suppl)
  • Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Changes of cardiovascular parameters during 90 degrees Head-up tilt in aging rats. (2015)
  • Author(s): Masao Yamasaki, H Nishimura, K Sakai, Hideki Imada, Hiroko Nomura.
  • Journal Title: JPS Volume: 65（suppl)
• [Journal Article] Spaceflight Affects Postnatal Development of the Aortic Wall in Rats． (2014)
  • Author(s): Shin-ichiro Katsuda, Masao Yamasaki, H Waki, M Miyake, H O-ishi, K Katahira,T Nagayama, Y Miyamoto, M Hasegawa, H Wago,T Okouchi, and T Shimizu．
  • Journal Title: Bio Med Research International, http://dx.doi.org/10.1155/2014/490428 Volume: Vol.2014
  • Peer Reviewed / Open Access
• [Presentation] Baroreflex response to blood pressure change due to postural transitions in aging rats: 90 degrees head-up tilt experiment (2017)
  • Author(s): 西村宗修、平岩徹也、嘉山裕介、酒井有理、橋本千穂、山崎将生
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ―浜松、浜松、静岡県
  • Year and Date: 2017-03-28
• [Presentation] DEVELOPMENTAL AND AGING CHARACTERISTICS OF THE CARDIOVASCULAR RESPONSES AFTER POSTURAL TRANSITIONS:EXPERIMENTS OF HEAD-UP OR HEAD-DOWN TILTING IN ANESTHETIZED RATS AND RABBITS (2017)
  • Author(s): Masao Yamasaki, T Shimizu、S Katusda, H Waki H Nishimura et al
  • Organizer: IUPS： 38th Int'l Union of Physiological Society, in Brazil
  • Int'l Joint Research
• [Presentation] 成長と老化過程の哺乳動物での体位変換に伴う循環因子の変化 (2017)
  • Author(s): Masao Yamasaki, T Shimizu、S Katusda, H Waki et al
  • Organizer: 第３1宇宙生物科学会大会、高崎
• [Presentation] Studies on the cardiovascular system and its regulations under real and simulated microgravity conditions in space and ground-based experiment (2016)
  • Author(s): Masao Yamasaki, Hidefumi Waki, Tsuyoshi Shimizu
  • Organizer: 11th Asian Microgravity Simposium
  • Place of Presentation: Sapporo Univ., Sapporo, Hokkaido Pref. , Japan
  • Year and Date: 2016-10-25
  • Int'l Joint Research
• [Presentation] Developmental characteristics of the changes in the cardiovascular parameters before, during and after 90 degrees head-up tilting in anesthetized rats (2016)
  • Author(s): Chiho Hashimoto, Yamasaki M, Hironobu Nishimura, Tetsuya Hiraiwa, Yuri Sakai, Yusuke Kayama
  • Organizer: 11th Asian Microgravity Simposium
  • Place of Presentation: Sapporo Univ., Sapporo, Hokkaido Pref. , Japan
  • Year and Date: 2016-10-25
  • Int'l Joint Research
• [Presentation] Developmental and age-related characteristics of the changes in cardiovascular parameters during Long-term 90 degrees head-up tilting in anesthetized rats (2016)
  • Author(s): Hironobu Nishimura, Tetsuya Hiraiwa, Masao Yamasaki, Chiho Hashimoto, Yuri Sakai, Yusuke Kayama
  • Organizer: 11th Asian Microgravity Simposium
  • Place of Presentation: Sapporo Univ., Sapporo, Hokkaido Pref. , Japan
  • Year and Date: 2016-10-25
  • Int'l Joint Research
• [Presentation] The fluctuation of arterial blood pressure after transition to supine posture from upright position in anesthetized rats (2016)
  • Author(s): Tetsuya Hiraiwa, Masao Yamasaki, Hironobu Nishimura, Chiho Hashimoto, Yuri Sakai, Yusuke Kayama
  • Organizer: 11th Asian Microgravity Simposium
  • Place of Presentation: Sapporo Univ., Sapporo, Hokkaido Pref. , Japan
  • Year and Date: 2016-10-25
  • Int'l Joint Research
• [Presentation] Baroreflex response to blood pressure change due to postural transitions in aging rats: 90 degrees head-up tilt experiment (2016)
  • Author(s): Masao Yamasaki, Hironobu Nishimura, Tetsuya Hiraiwa
  • Organizer: .Joint conference Meeting"Life in space for life on earth" 14th European Life Sci. Symposium & 37 th Gravtational Physiol.), Touelouse, France
  • Place of Presentation: Touelouse Centre, Touelouse, France
  • Year and Date: 2016-06-06
  • Int'l Joint Research
• [Presentation] Baroreflex response to arterial pressure changes due to postural transitions in aging rats: 90 degrees head-up tilt experiment (2016)
  • Author(s): Masao Yamasaki, Hironobu Nishimura, Tetsuya Hiraiwa.
  • Organizer: Joint Life Science Meeting:Life in Space for Life on Earth, the 37th Annual International Gravitational Physiology Meeting and the 14th European Life Sciences Symposium
  • Place of Presentation: Toulouse, France
  • Year and Date: 2016-06-05
  • Int'l Joint Research
• [Presentation] Structural, Functional and Developmental Characteristics of Aortic Baroreceptor reflex :Review on Baroreflex Afferent and Its Reflex Mechanisms under Several Environmental Conditions in Rats and Rabbits. (2016)
  • Author(s): Masao Yamasaki, Tsuyoshi Shimizu.
  • Organizer: The 31th Joint Annual Conference of Biomedical Science
  • Place of Presentation: National Defense Med. Univ., Taiwan, China
  • Year and Date: 2016-03-26
  • Int'l Joint Research
• [Presentation] 麻酔下ラットにおける90°Head-up tiltから仰臥位に変えた時の循環因子変化. (2016)
  • Author(s): 平岩徹也, 西村宗修, 山崎将生.
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター、札幌
  • Year and Date: 2016-03-22
• [Presentation] 麻酔下老齢ラットでは90°Head-up tilt時の血圧維持能が低い. (2016)
  • Author(s): 西村宗修, 山崎将生, 平岩徹也, 水谷夏希, 伊藤康宏.
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター、札幌
  • Year and Date: 2016-03-22
• [Presentation] Changes of blood pressure, blood flow and heart rate during 90°head-up tilt for 30 min in anesthetized rats (2015)
  • Author(s): Hironobu Nishimura, Masao Yamasaki, Tetsuya Hiraiwa.
  • Organizer: 8th FAOPS：アジア生理科学会議
  • Place of Presentation: Bangkok, Thai
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] 加齢ラットにおける90°Head-up tiltに対する循環応答. Cardiovascular parameters in response to the 90 degrees head-up tilt in anesthetized aging rats. (2015)
  • Author(s): Natsuki Kamiya-Mizutani, Hironobu Nishimura, Tetsuya Hiraiwa2, Yasuhiro Itoh, Masao Yamasaki.
  • Organizer: 日本宇宙生物科学会第29回大会
  • Place of Presentation: 帝京大学、東京
  • Year and Date: 2015-09-26
• [Presentation] Changes of cardiovascular parameters during 90 degrees Head-up tilt in aging rats. (2015)
  • Author(s): Masao Yamasaki, H Nishimura, K Sakai, H Imada, H Nomura.
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] Cardiovascular changes and neural regulation in response to the 90 degrees head-up tilt in anesthetized rats. 、 (2014)
  • Author(s): Yamasaki M and Nishimura H
  • Organizer: 10th Asian Microgravity Simposium
  • Place of Presentation: Seoul,Koria
  • Year and Date: 2014-10-21 – 2014-10-25