Development of the countermeasure for musculoskeletal atrophy in outer space

• Project/Area Number: 26506025
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 宇宙生命学
• Research Institution: Kurume University
• Principal Investigator: Shiba Naoto 久留米大学, 医学部, 教授 (20187389)
• Co-Investigator(Kenkyū-buntansha): 高野 吉朗 国際医療福祉大学, 福岡保健医療学部, 准教授 (20439574) ; 田川 善彦 久留米大学, 医学部, 客員教授 (70122835)
• Research Collaborator: Matsuse Hiroo ; Hashida Ryuki ; Omoto Masayuki ; Yamamoto Naosuke
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: 廃用予防 / 筋力増強運動 / エルゴメータ / 有酸素運動 / 宇宙医学 / 呼気ガス分析 / 微小重力 / 表面電気刺激 / 抵抗運動 / 電気刺激 / 成長ホルモン / インターロイキンー６ / インターロイキン６

Outline of Final Research Achievements

Hybrid training System (HTS) is to create resistance to the motion of a volitionally contracting agonist muscle by means of the force generated by its electrical stimulated eccentric antagonist muscle. We developed the new training method that HTS is combined with a cycle ergometer (HCE). HCE stimulated acute increases in growth hormone, lactate and IL-6 than conventional ergometer at the same workload. Moreover, HCE improved the peak oxygen uptake and knee muscle strength with the training program used in orbit (30-min HCE at a 3-time session a week for 6 weeks ). The change of knee extension strength by HCE was greater than by a ergometer exercise without HTS. We simulated that HCE effectively increased the oxygen uptake in a linear manner, and additional stimulation of muscles at the ankle joint increased the oxygen uptake. In the flight experiment, we confirmed that HCE was performed without a problem. HCE seems to be a useful method in orbit or space flight.

Research Products

• [Journal Article] 拮抗筋電気刺激を有するサイクリング運動モデルによる酸素摂取量のシミュレーション (2017)
  • Author(s): 田川善彦，山本直輔，大本将之，，松瀬博夫，高野吉朗，志波直人
  • Journal Title: 宇宙航空環境医学 Volume: 未定
  • Peer Reviewed
• [Presentation] Simulation of Oxygen Uptake and Leg Joint Reaction Force During Ergometer Exercise under Altered Gravity (2017)
  • Author(s): Yoshihiko Tagawa, Naosuke Yamamoto, Masayuki Omoto, Hiroo Matsuse, Naoto Shiba
  • Organizer: 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Jeju Island, Korea
  • Year and Date: 2017-07-11
  • Int'l Joint Research
• [Presentation] Electrical Stimulation of the Antagonist Muscle added to Ergometer Training Improves Oxygen Uptake and Muscle Strength. (2016)
  • Author(s): 橋田竜騎
  • Organizer: American Congress of Rehabilitation Medicine ACRM 93rd Annual Conference
  • Place of Presentation: アメリカ、シカゴ
  • Year and Date: 2016-10-30
  • Int'l Joint Research