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Development of the countermeasure for musculoskeletal atrophy in outer space

Research Project

Project/Area Number 26506025
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 宇宙生命学
Research InstitutionKurume University

Principal Investigator

Shiba Naoto  久留米大学, 医学部, 教授 (20187389)

Co-Investigator(Kenkyū-buntansha) 高野 吉朗  国際医療福祉大学, 福岡保健医療学部, 准教授 (20439574)
田川 善彦  久留米大学, 医学部, 客員教授 (70122835)
Research Collaborator Matsuse Hiroo  
Hashida Ryuki  
Omoto Masayuki  
Yamamoto Naosuke  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords廃用予防 / 筋力増強運動 / エルゴメータ / 有酸素運動 / 宇宙医学 / 呼気ガス分析 / 微小重力 / 表面電気刺激 / 抵抗運動 / 電気刺激 / 成長ホルモン / インターロイキンー6 / インターロイキン6
Outline of Final Research Achievements

Hybrid training System (HTS) is to create resistance to the motion of a volitionally contracting agonist muscle by means of the force generated by its electrical stimulated eccentric antagonist muscle. We developed the new training method that HTS is combined with a cycle ergometer (HCE). HCE stimulated acute increases in growth hormone, lactate and IL-6 than conventional ergometer at the same workload. Moreover, HCE improved the peak oxygen uptake and knee muscle strength with the training program used in orbit (30-min HCE at a 3-time session a week for 6 weeks ). The change of knee extension strength by HCE was greater than by a ergometer exercise without HTS. We simulated that HCE effectively increased the oxygen uptake in a linear manner, and additional stimulation of muscles at the ankle joint increased the oxygen uptake. In the flight experiment, we confirmed that HCE was performed without a problem. HCE seems to be a useful method in orbit or space flight.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] 拮抗筋電気刺激を有するサイクリング運動モデルによる酸素摂取量のシミュレーション2017

    • Author(s)
      田川善彦,山本直輔,大本将之,,松瀬博夫,高野吉朗,志波直人
    • Journal Title

      宇宙航空環境医学

      Volume: 未定

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] Simulation of Oxygen Uptake and Leg Joint Reaction Force During Ergometer Exercise under Altered Gravity2017

    • Author(s)
      Yoshihiko Tagawa, Naosuke Yamamoto, Masayuki Omoto, Hiroo Matsuse, Naoto Shiba
    • Organizer
      39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Jeju Island, Korea
    • Year and Date
      2017-07-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrical Stimulation of the Antagonist Muscle added to Ergometer Training Improves Oxygen Uptake and Muscle Strength.2016

    • Author(s)
      橋田竜騎
    • Organizer
      American Congress of Rehabilitation Medicine  ACRM 93rd Annual Conference
    • Place of Presentation
      アメリカ、シカゴ
    • Year and Date
      2016-10-30
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2018-03-22  

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