Exploration of the molecules responding to space environment and the critical points in development of nematodes
Project/Area Number |
26506029
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
宇宙生命学
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Research Institution | Japan Aerospace EXploration Agency |
Principal Investigator |
Higashibata Akira 国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 主任研究開発員 (30360720)
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Research Collaborator |
HIGASHITANI Atsushi
HASHIZUME Toko
UMEHARA Masumi
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 微小重力 / 線虫 / トランスクリプトーム / クリティカルポイント / 筋萎縮 |
Outline of Final Research Achievements |
In the past space flight experiments, we observed the effects of microgravity on the genes expression related with muscles and energy metabolisms. The purpose of this study is to know the molecules that were influenced by gravity changes, and to investigate the critical points on the developmental process of Caenorhabditis elegans known as a model organism. The worms were grown under artificial microgravity condition on a clinostat that was an apparatus widely used for experiments for gravity effects on the ground. The expression level of body morphogenesis related genes showed the changes in the early developmental phase by clinorotation. The result suggested that the body morphogenetic process was sensitive against the gravity changes. During the latter half of the developmental phase of the worms, the artificial microgravity effects were observed on the molecules related with protein phosphorylation that had been also observed in the space experiments.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans2016
Author(s)
Higashibata A., Hashizume T., Nemoto K., Higashitani N., Etheridge T., Mori C., Harada S., Sugimoto T., Szewczyk NJ., Baba SA., Mogami Y., Fukui K., Higashitani A.
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Journal Title
npj Microgravity
Volume: 2
Issue: 1
Pages: 15022-15022
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Alteration of muscle, cytoskeleton, and mitochondria evokes caloric restriction in spaceflown nematodes2016
Author(s)
Akira Higashibata, Toko Hashizume, Kanako Nemoto, Nahoko Higashitani, Timothy Etheridge, Chihiro Mori, Tomoko Sugimoto, Nathaniel Szewczyk, Shoji Baba, Yoshihiro Mogami, Keiji Fukui, Atsushi Higashitani
Organizer
11th Asian Microgravity Symposium
Place of Presentation
Hokkaido University
Year and Date
2016-10-25
Related Report
Int'l Joint Research
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[Presentation] Alteration of Muscle, Cytoskeleton, and Mitochondoria Evokes Carolic Restriction in Spaceflown Nematodes2016
Author(s)
Higashibata A., Hashizume T., Nemoto K., Higashitani N., Etheridge T., Mori C., Harada S., Sugimoto T., Szewczyk NJ., Baba SA., Mogami Y., Fukui K., Higashitani A.
Organizer
11th Asian Microgravity Symposium
Place of Presentation
Hokkaido University
Year and Date
2016-10-25
Related Report
Int'l Joint Research
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