| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In the past space flight experiments, we observed the effects of microgravity on the genes expression related with muscles and energy metabolisms. The purpose of this study is to know the molecules that were influenced by gravity changes, and to investigate the critical points on the developmental process of Caenorhabditis elegans known as a model organism. The worms were grown under artificial microgravity condition on a clinostat that was an apparatus widely used for experiments for gravity effects on the ground.
The expression level of body morphogenesis related genes showed the changes in the early developmental phase by clinorotation. The result suggested that the body morphogenetic process was sensitive against the gravity changes. During the latter half of the developmental phase of the worms, the artificial microgravity effects were observed on the molecules related with protein phosphorylation that had been also observed in the space experiments.
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