Study on the network of longevity control genes expressed under space environments

• Project/Area Number: 26506033
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 宇宙生命学
• Research Institution: Waseda University (2016); Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2014-2015)
• Principal Investigator: Honda Shuji 早稲田大学, 理工学術院総合研究所(理工学研究所), その他(招聘研究員) (40100127)
• Co-Investigator(Kenkyū-buntansha): 本田 陽子 早稲田大学, 理工学術院総合研究所(理工学研究所), その他(招聘研究員) (90399460)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 宇宙 / 線虫 / 老化 / 重力 / 寿命 / 遺伝子

Outline of Final Research Achievements

Space environments down regulate the expression of more than ten neuronal genes in the nematode Caenorhabditis elegans. We investigated the involvement of these genes in aging and gravity. We examined the effects of aging, mutation in daf-16, the downstream of insulin/IGF signaling, and hypergravity: 100G. These genes responded in various ways to aging, insulin/IGF signaling and hypergravity.

Research Products

• [Journal Article] Diapause is associated with a change in the polarity of secretion of insulin-like peptides (2016)
  • Author(s): Yohei Matsunaga, Yoko Honda, Shuji Honda, Takashi Iwasaki, Hiroshi Qadota, Guy M. Benian Tsuyoshi Kawano
  • Journal Title: Nature Communications Volume: 7 Issue: 1 Pages: 10573-10573
  • DOI: 10.1038/ncomms10573
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling. (2015)
  • Author(s): Honda Y, Araki Y, Hata T, Ichihara K, Ito M, Tanaka M, Honda S.
  • Journal Title: Journal Aging Research Volume: 2015 Pages: 425261-425261
  • DOI: 10.1155/2015/425261
  • Peer Reviewed / Open Access
• [Journal Article] Spaceflight and aging (2014)
  • Author(s): Honda Y, Honda S, Narici M, Szewczyk NJ,
  • Journal Title: Gerontology Volume: 60 Issue: 2 Pages: 138-142
  • DOI: 10.1159/000354772
  • Peer Reviewed / Open Access
• [Presentation] 10-Hydroxy-2-decenoic acid, a unique fatty acid in royal jelly, extends lifespan in nematode C. elegans (2015)
  • Author(s): Taketoshi Hata, Hiroe Maruyama, Yoko Araki, Yoko Honda, Shuji Honda, Kenji Ichihara
  • Organizer: Apimondia
  • Place of Presentation: Daejeon, Korea
  • Year and Date: 2015-09-15
  • Int'l Joint Research
• [Presentation] Aging in Space. (2014)
  • Author(s): Honda Y, Higashibata A, Matsunaga Y, Yonezawa Y, Kawano T, Higashitani A, Kuriyama K, Shimazu T, Tanaka M, Szewczyk N J, Ishioka N, Honda S,
  • Organizer: C. elegans Development, Cell Biology & Gene Expression Meeting in association with The 6th Asia-Pacific C. elegans Meeting,
  • Place of Presentation: 奈良、奈良県立公会堂
  • Year and Date: 2014-07-15 – 2014-07-19
• [Presentation] 老化促進モデルマウス（ SAMP10）におけるトレハロースの長期投与の加齢指標におよぼす影響 (2014)
  • Author(s): 本田陽子、本田修二、濱野慶朋、長谷川康子、新井冨生、田中雅嗣
  • Organizer: 老化促進モデルマウス（ SAM）研究協議会第29回研究発表会
  • Place of Presentation: 東京、東京都健康長寿医療センター
  • Year and Date: 2014-07-05 – 2014-07-06
• [Book] 老化の生物学 第10章 インスリンシグナル (2014)
  • Author(s): 本田陽子、本田修二、河野強
  • Total Pages: 20
  • Publisher: 化学同人