Development of integrated chronotbiotic therapy on delayed sleep phase disorder
| Project/Area Number |
26507012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
睡眠科学
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| Research Institution | Nihon University |
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Principal Investigator |
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| Research Collaborator |
KONNO Michiko
SUZUKI Masahiro
FURIHATA Ryuji
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 概日リズム / 睡眠障害 / 不眠 / 起床困難 / メラトニン / オレキシン / 高照度光療法 / 時間療法 |
|---|
| Outline of Final Research Achievements |
Delayed sleep phase type, a circadian rhythm sleep disorder is a condition in which the patient is unable to reset or phase-advance his/her sleep timing properly after transient sleep delay and consequently shows persistent sleep phase delay. Prior studies suggested that delayed sleep phase type is associated with a phase delay in the circadian pacemaker, but there was no evidence to explain the patient’s inability to reset sleep phase. There have been no fundamental biological differences that could explain why patients with delayed sleep phase type fail to reset their sleep phase according to personal or social demands. The results obtained in the present study suggest that an ability to rise sleep pressure according to length of the prior wakefulness was associated with the patient’s difficulty in properly advancing his/her sleep timing. Further research is needed to develop a therapy that can correct both circadian and homeostatic abnormalities in delayed phase type.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Association of short sleep duration and short time in bed with depression: A Japanese general population survey2015
Author(s)
Furihata R, Uchiyama M, Suzuki M, Konno C, Konno M, Takahashi S, Kaneita Y, Ohida T, Akahoshi T, Hashimoto S, Akashiba T
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Journal Title
Sleep Biol Rhythm
Volume: in press
Issue: 2
Pages: 136-145
DOI
Related Report
Peer Reviewed
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[Journal Article] Screening of Clock Gene Polymorphisms Demonstrates Association of a PER3 Polymorphism with Morningness-Eveningness Preference and Circadian Rhythm Sleep Disorder2014
Author(s)
Hida A, Kitamura S, Katayose Y, Kato M, Ono H, Kadotani H, Uchiyama M, Ebisawa T, Inoue Y, Kamei Y, Okawa M, Takahashi K, Mishima K
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Journal Title
Scientific Reports
Volume: 4(6309)
Issue: 1
Pages: 1-6
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] うつ病と睡眠の関連2016
Author(s)
内山真
Organizer
第29回 日本総合病院精神医学会学術総会
Place of Presentation
日本教育会館
Year and Date
2016-11-26
Related Report
Invited
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[Presentation] 体内時計と不眠症2016
Author(s)
内山真
Organizer
第43回日本神経内分泌学会学術集会
Place of Presentation
アクトシティ浜松 コングレスセンター
Year and Date
2016-10-15
Related Report
Invited
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[Presentation] がん患者の不眠2015
Author(s)
内山 真
Organizer
日本緩和医療学会 第19回教育セミナー
Place of Presentation
パシフィコ横浜（神奈川県横浜市）
Year and Date
2015-06-18
Related Report
Invited
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[Presentation] ヒトの体温調節と睡眠2014
Author(s)
内山真
Organizer
第79回日本温泉気候物理医学会・学術集会
Place of Presentation
京都国際会議場（京都府京都市）
Year and Date
2014-05-12
Related Report
Invited
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