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A mathematical model of the jigsaw puzzle appearance of Arabidopsis leaf pavement cells

Research Project

Project/Area Number 26520207
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section特設分野
Research Field Mathematical Sciences in Search of New Cooperation
Research InstitutionKyushu University

Principal Investigator

Takigawa-Imamura Hisako  九州大学, 医学研究院, 助教 (30523790)

Co-Investigator(Renkei-kenkyūsha) KUTSUNA Natsumaro  東京大学, 大学院新領域創成科学研究科, 特任准教授 (70578559)
KOBARASHI Ryo  広島大学, 大学院理学研究科, 教授 (60153657)
MIURA Takashi  九州大学, 大学院医学研究院, 教授 (10324617)
Project Period (FY) 2014-07-18 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords数理モデル / 植物細胞壁 / 葉表皮細胞 / 形態形成 / 座屈 / シロイヌナズナ / 反応拡散 / 画像解析 / 細胞間応力 / 曲げ弾性
Outline of Final Research Achievements

We investigated the mechanism of the formation of the jigsaw puzzle-like morphology in pavement cells in dicotyledonous plants by using a mathematical model. We developed the mathematical model that considers the balance between cell and cell wall growth, restricted global cell growth orientation, and regulation of local cell outgrowth mediated by a Rho-like GTPase-cytoskeleton system. Our computational simulations suggest that interdigitated patterns form because of mechanical buckling in the absence of Rho-like GTPase-dependent regulation of local cell outgrowth. Our model clarifies the cell wall mechanics influencing pavement cell morphogenesis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Exogenous cellulase switches cell interdigitation to cell elongation in a RIC1-dependent manner in Arabidopsis thaliana cotyledon pavement cells.2017

    • Author(s)
      Higaki T, Takigawa-Imamura H, Akita K, Kutsuna N, Kobayashi R, Hasezawa S, Miura T
    • Journal Title

      Plant Cell Physiol

      Volume: 58 Pages: 106-119

    • DOI

      10.1093/pcp/pcw183

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition.2017

    • Author(s)
      Fumoto, K., Takigawa-Imamura, H., Sumiyama, K., Kaneiwa, T., and Kikuchi, A.
    • Journal Title

      Development

      Volume: 144 Pages: 151-162

    • DOI

      10.1242/dev.141325

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Theoretical Model of Jigsaw-Puzzle Pattern Formation by Plant Leaf Epidermal Cells2016

    • Author(s)
      Takumi Higaki, Natsumaro Kutsuna, Kae Akita, Hisako Takigawa-Imamura, Kenji Yoshimura, Takashi Miura
    • Journal Title

      PLOS Computational Biology

      Volume: 12 Issue: 4 Pages: e1004833-e1004833

    • DOI

      10.1371/journal.pcbi.1004833

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 血管新生現象を利用した組織;マイクロ流路間の接続と灌流培養への取り組み2016

    • Author(s)
      梨本裕司, 國田樹, 中益朗子, 鳥澤勇介, 中山雅宗, 今村(滝川)寿子, 小寺秀俊, 西山功一, 三浦岳, 横川隆司
    • Journal Title

      化学とマイクロ・ナノシステム

      Volume: 15 Pages: 19-22

    • Related Report
      2015 Research-status Report
  • [Journal Article] Tooth germ invagination from cell-cell interaction: Working hypothesis on the mechanical instability2015

    • Author(s)
      Hisako Takigawa-Imamura, Ritsuko Morita, Takafumi Iwaki, Takashi Tsuji and Kenichi Yoshikawa
    • Journal Title

      Journal of Theoretical Biology

      Volume: 382 Pages: 284-291

    • DOI

      10.1016/j.jtbi.2015.07.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Emergence of hierarchical structure of lung: a model and observation of cellular response to FGF2016

    • Author(s)
      Hisako Takigawa-Imamura
    • Organizer
      2016年日本数理生物学会年会
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肺上皮FGF応答活性の測定と分岐形成数理モデル化2016

    • Author(s)
      今村(滝川)寿子
    • Organizer
      「がん研究分野の特性等を踏まえた支援活動」公開シンポジウム
    • Place of Presentation
      一橋講堂(千代田区)
    • Year and Date
      2016-02-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 葉表皮細胞のジグソーパズル構造形成の数理モデル2015

    • Author(s)
      今村(滝川)寿子、桧垣匠、朽名夏麿、秋田佳恵、小林亮、三浦岳
    • Organizer
      第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸国際展示場(神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Research-status Report
  • [Presentation] Observation of FGF response in lung epithelium and modeling for branching morphogenesis2015

    • Author(s)
      Takigawa-Imamura H
    • Organizer
      The second international meeting for epithelial tubulology
    • Place of Presentation
      札幌大学(札幌市)
    • Year and Date
      2015-08-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Observation of FGF response in lung epithelium and modeling for branching morphogenesis2015

    • Author(s)
      今村(滝川)寿子
    • Organizer
      第48回日本発生生物学会大会(APDBN共催)
    • Place of Presentation
      つくば国際会議場(つくば市)
    • Year and Date
      2015-06-03
    • Related Report
      2015 Research-status Report
  • [Presentation] A Mathematical Model of the Jigsaw Puzzle Appearance of Arabidopsis Leaf Pavement Cells2015

    • Author(s)
      Hisako Takigawa-Imamura, Natsumaro Kutsuna, Takumi Higaki, Kae Akita, Takashi Miura
    • Organizer
      第56回日本植物生理学会年会
    • Place of Presentation
      東京農業大学 世田谷キャンパス
    • Year and Date
      2015-03-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Jigsaw Puzzle Pattern in the Epidermal Cell Wall of Leaves2014

    • Author(s)
      Hisako Takigawa-Imamura, Natsumaro Kutsuna, Takumi Higaki, Kae Akita, Takashi Miura
    • Organizer
      The 62nd NIBB Conference
    • Place of Presentation
      岡崎コンファレンスセンター
    • Year and Date
      2014-11-17
    • Related Report
      2014 Research-status Report

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Published: 2014-09-09   Modified: 2018-03-22  

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