| Project/Area Number |
26540150
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
Takinoue Masahiro 東京工業大学, 総合理工学研究科(研究院), 准教授 (20511249)
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| Co-Investigator(Renkei-kenkyūsha) |
Morita Masamune 日本学術振興会, 特別研究員 (90708504)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 人工細胞モデル / マイクロ・ナノデバイス / 非平衡 / 非線形 / マイクロフルイディクス / エマルション |
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| Outline of Final Research Achievements |
In this study, we developed microfluidic control systems for generation of liposomes (artificial cell-membrane vesicles), control of chemical reactions in artificial cell-like vesicles, and molecular interaction between artificial cell-like vesicles. In the study of the generation of liposomes, we developed a centrifugal capillary-based microfluidic device. We demonstrated that the centrifugal capillary-based microfluidic device could generate cell-sized monodisperse liposomes. In the study of the control of chemical reactions, we demonstrated a chemical rhythm reaction could be controlled based on computer-aided fusion and fission of microdroplet-based artificial cell-like vesicles. By extending this method, we demonstrated the interaction between microdroplet-based artificial cell-like vesicles.
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