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Construction of an intelligent reaction system for molecular cancer diagnosis

Research Project

Project/Area Number 26540151
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Life / Health / Medical informatics
Research InstitutionTokyo Institute of Technology

Principal Investigator

Komiya Ken  東京工業大学, 情報理工学院, 助教 (20396790)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsDNAコンピュータ / DNAナノテクノロジー / 核酸増幅法 / 分子状態機械 / 早期診断 / DNAコンピュータ
Outline of Final Research Achievements

In this study, we constructed and investigated an intelligent reaction system for allowing molecules to process information of transcription pattern and conduct cancer diagnosis. The present reaction system consists of a nucleic acid amplification method and a molecular state machine. In the development of nucleic acid amplification method, we achieved suppression of undesired non-specific amplification, improved reaction specificity and extended variation of detectable forms of nucleic acids. Finally, we improved the sensitivity of detection. In the development of molecular state machine, we revealed factors that affect the reaction efficiency and revised the design of reaction system. Optimization of reaction conditions is continuously implemented.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (22 results)

All 2016 2015 2014 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 3 results,  Open Access: 2 results) Presentation (14 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Analysis and design of a single-molecule DNA nanodevice for thermal band-pass filters2016

    • Author(s)
      J. A. Rose, K. Komiya
    • Journal Title

      Proceedings of the 11th IEEE Annual International Conference on Nano/Micro Engineered and Molecular Systems

      Volume: - Pages: 79-84

    • DOI

      10.1109/nems.2016.7758205

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Engineering multistate DNA molecules: a tunable thermal band-pass filter2016

    • Author(s)
      J. A. Rose, K. Komiya, S. Kobayashi
    • Journal Title

      Micro & Nano Letters

      Volume: 11 Issue: 10 Pages: 595-601

    • DOI

      10.1049/mnl.2016.0345

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] DNAナノマシン2016

    • Author(s)
      小宮 健
    • Journal Title

      現代化学

      Volume: 548 Pages: 32-35

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Cascading DNA Generation Reaction for Controlling DNA Nanomachines at a Physiological Temperature2015

    • Author(s)
      Ken Komiya and Masayuki Yamamura
    • Journal Title

      New Generation Computing

      Volume: 33 Issue: 3 Pages: 213-229

    • DOI

      10.1007/s00354-015-0304-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 好熱性細菌を対象としたリボソームの立体構造比較2016

    • Author(s)
      若林優太,小宮健,山村雅幸
    • Organizer
      極限環境生物学会2016年度(第17回)年会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 翻訳機構の進化過程解明に向けたリボソームの立体構造比較2016

    • Author(s)
      小宮健,若林優太,山村雅幸
    • Organizer
      「細胞を創る」研究会9.0
    • Place of Presentation
      東京都新宿区
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Construction of an isothermal DNA amplification reaction system for simplified nucleic acid test2016

    • Author(s)
      K. Komiya, C. Noda, M. Komori, K. Dong, T. Takenaka, T. Enomoto, T. Yoshimura, M. Yamamura
    • Organizer
      第10回バイオ関連化学シンポジウム
    • Place of Presentation
      石川県立音楽堂
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Autonomous and Programmable Strand Generator Implemented as DNA Chemical Reaction Network2016

    • Author(s)
      ] I. Kawamata, S. Kawakami, Y.-C. Chen, S. Hiratsuka, S. Aradachi, D. Tamatsuki, H. Yuuki, T. Takahashi, E. Ishihara, S. Imai, H. Otaka, Y. Otaki, K. Suzuki, T. Watanabe, K. Komiya, F. Takabatake, S. Nomura, S. Murata
    • Organizer
      Twentysecond International Meeting on DNA Computing and Molecular Programming (DNA22)
    • Place of Presentation
      Munich
    • Year and Date
      2016-09-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis and Design of a Single-Molecule DNA Nanodevice for Thermal Band-Pass Filters2016

    • Author(s)
      J. A. Rose, K. Komiya
    • Organizer
      The 11th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS 2016)
    • Place of Presentation
      Matsushima Bay and Sendai MEMS City
    • Year and Date
      2016-04-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] DNAシグナル生成反応の展開2015

    • Author(s)
      小宮健
    • Organizer
      人工知能学会合同研究会 第59回分子生物情報研究会(SIG-MBI)
    • Place of Presentation
      横浜市
    • Year and Date
      2015-11-14
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Construction of a DNA Generation Circuit for a Molecular Robot2015

    • Author(s)
      Ken Komiya, Chizuru Noda and Masayuki Yamamura
    • Organizer
      CBI学会2015年大会
    • Place of Presentation
      東京都江戸川区
    • Year and Date
      2015-10-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Construction of a DNA generation reaction system for autonomous DNA-based computing at a physiological temperature2015

    • Author(s)
      Ken Komiya, Kesu Dong, Toshio Takenaka and Masayuki Yamamura
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢市
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
  • [Presentation] 高感度核酸検査に向けた等温指数増幅反応系の構築2015

    • Author(s)
      小宮健,他5名
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      日本大学理工学部 船橋キャンパス, 船橋市
    • Year and Date
      2015-03-26
    • Related Report
      2014 Research-status Report
  • [Presentation] DNAナノマシンによる歩行動作の温度特性の検証2014

    • Author(s)
      外舘悠仁,小宮健,山村雅幸
    • Organizer
      日本機械学会 第6回マイクロ・ナノ工学シンポジウム
    • Place of Presentation
      くにびきメッセ,松江市
    • Year and Date
      2014-10-21
    • Related Report
      2014 Research-status Report
  • [Presentation] DNA応答型ナノマシンの動作を指定するDNAシグナル生成機構の構築2014

    • Author(s)
      小宮健,山村雅幸
    • Organizer
      日本機械学会 第6回マイクロ・ナノ工学シンポジウム
    • Place of Presentation
      くにびきメッセ,松江市
    • Year and Date
      2014-10-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Analog DNA Computing Devices Toward the Control of Molecular Robots2014

    • Author(s)
      Satoshi Kobayashi, Kazuya Yanagibashi, Kenzo Fujimoto, Ken Komiya and Masami Hagiya
    • Organizer
      Workshop on Self-organization in Swarm of Robots: from Molecular Robots to Mobile Agents (WSSR 2014)
    • Place of Presentation
      Todaiji Culture Center, Nara
    • Year and Date
      2014-10-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Implementation of in vitro intelligence for real-time operation of molecular robots2014

    • Author(s)
      Ken Komiya
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター,札幌市
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] A Sequential DNA Generation Circuit for Directing DNA Nanomachines2014

    • Author(s)
      Ken Komiya, Erimi Harada and Masayuki Yamamura
    • Organizer
      Twentieth International Meeting on DNA Computing and Molecular Programming (DNA20)
    • Place of Presentation
      Kyoto University, Kyoto
    • Year and Date
      2014-09-22 – 2014-09-25
    • Related Report
      2014 Research-status Report
  • [Book] DNA分子デザインのすべて~BIOMOD虎の巻~2016

    • Author(s)
      村田智, 浜田省吾, 小宮健, ほか全21名
    • Total Pages
      224
    • Publisher
      情報計算化学生物学会(CBI学会)出版
    • Related Report
      2016 Annual Research Report
  • [Remarks] Bio-Inspired Chemistry

    • URL

      http://bio-inspired.chemistry.jpn.com/

    • Related Report
      2016 Annual Research Report
  • [Remarks]

    • URL

      http://bio-inspired.chemistry.jpn.com/

    • Related Report
      2015 Research-status Report
  • [Remarks]

    • URL

      http://bio-inspired.chemistry.jpn.com/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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