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Programing of cellular behavior via positive feedback consisting of two cell types

Research Project

Project/Area Number 26540152
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Life / Health / Medical informatics
Research InstitutionWaseda University (2016)
Tokyo Institute of Technology (2014-2015)

Principal Investigator

Kiga Daisuke  早稲田大学, 理工学術院, 教授 (30376587)

Research Collaborator Ayukawa Shotaro  早稲田大学, 理工学術院, 次席研究員
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords合成生物学 / 数理モデル / 細胞間コミュニケーション / 細胞間コミニュケーション / 遺伝暗号 / リボソーム / tRNA / 直交性
Outline of Final Research Achievements

In this synthetic biology study, we implemented a positive feedback system consisting of two cell types. When type A cell receives a cell-cell communication molecule from the type B cell, type A cell releases the other communication molecule which activates release from type B cell.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (9 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] A Bacterial Continuous Culture System Based on a Microfluidic Droplet Open Reactor2016

    • Author(s)
      Manami Ito,Haruka Sugiura, Shotaro Ayukawa, Daisuke Kiga,Masahiro Takinoue
    • Journal Title

      Analytical Sciences

      Volume: 32 Issue: 1 Pages: 61-66

    • DOI

      10.2116/analsci.32.61

    • NAID

      130005118567

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 設計生物学2016

    • Author(s)
      木賀大介
    • Journal Title

      人工細胞の創製とその応用

      Volume: . Pages: 187-198

    • Related Report
      2016 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] RNAワールドの成立・維持と発展的解消2016

    • Author(s)
      木賀大介
    • Journal Title

      細胞工学

      Volume: 35 Pages: 111-115

    • Related Report
      2015 Research-status Report
  • [Journal Article] Effects of downstream genes on synthetic genetic circuits2014

    • Author(s)
      Takefumi Moriya, Masayuki Yamamura, Daisuke Kiga
    • Journal Title

      BMC Systems Biology

      Volume: 8(suppl 4) Issue: S4 Pages: 1-10

    • DOI

      10.1186/1752-0509-8-s4-s4

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 生物をつくることで生命を理解する2014

    • Author(s)
      木賀大介
    • Journal Title

      コトバ

      Volume: 2014夏号 Pages: 78-81

    • Related Report
      2014 Research-status Report
  • [Presentation] 設計生物学 ― 博物学ではない生物学の構築2017

    • Author(s)
      木賀大介
    • Organizer
      第2回 デザイン生命工学研究会
    • Place of Presentation
      神戸大学統合研究拠点
    • Year and Date
      2017-03-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effects of downstream genes on synthetic genetic circuits2017

    • Author(s)
      Takefumi Moriya, Zicong Zhang, ○Shotaro Ayukawa, Masayuki Yamamura, Daisuke Kiga
    • Organizer
      Effects of downstream genes on synthetic genetic circuits
    • Place of Presentation
      神戸大学統合研究拠点
    • Year and Date
      2017-03-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] Systems biology : Synthetic biology = Systems chemistry : ???2017

    • Author(s)
      Daisuke Kiga
    • Organizer
      ELSI symposium
    • Place of Presentation
      Tokyo Tech
    • Year and Date
      2017-01-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 設計生物学と進化工学のあいだ2016

    • Author(s)
      木賀大介
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-12-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] 多細胞合成生物学2016

    • Author(s)
      木賀大介
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2016-11-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 合成生物学についての大学教育2016

    • Author(s)
      木賀大介
    • Organizer
      日本遺伝学会第88回大会
    • Place of Presentation
      日本大学国際関係学部 三島駅北口校舎
    • Year and Date
      2016-09-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] Designing Life2016

    • Author(s)
      Daisuke Kiga
    • Organizer
      Gordon Research Conference Origins of Life
    • Place of Presentation
      Hotel Galvez Galveston, TX, USA
    • Year and Date
      2016-01-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 生命の起源と初期進化における、情報と「知能」の出現2015

    • Author(s)
      木賀大介
    • Organizer
      分子ロボティクスシンポジウム(CBI学会第25回大会内)
    • Place of Presentation
      東京都江戸川区 タワーホール船堀
    • Year and Date
      2015-10-28
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 数理モデルに基づいて生体高分子ネットワークを実装する2014

    • Author(s)
      木賀大介
    • Organizer
      総研大「生命概念の普遍化-宇宙の生命」第5回研究会
    • Place of Presentation
      広島大学学士会館・広島県
    • Year and Date
      2014-06-19
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-12-17  

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