Modelling viscoelastic dynamics of organ morphogenesis and its numerical analysis
| Project/Area Number |
26540158
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Life / Health / Medical informatics
|
|---|
| Research Institution | Akita Prefectural University (2015-2016)
The Institute of Physical and Chemical Research (2014) |
|---|
Principal Investigator |
Ishimoto Yukitaka 秋田県立大学, システム科学技術学部, 准教授 (30391858)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SUGIMURA Kaoru 京都大学, 物質-細胞統合システム拠点, 助教 (50466033)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 生命情報 / 細胞・組織・器官 / 構造・パターン形成 / コンピュータシミュレーション / 数理生物学 / 生物物理 / 発生・分化 / 粘弾性 / 形態形成 / 数理モデル / データ解析 / 動力学モデル / 器官形態形成 / 生体情報 / 生体工学 / 発生生物学 |
|---|
| Outline of Final Research Achievements |
We have formulated a mechanical model of Drosophila wing margin shape by modelling the margin as a string-like object with bending stiffness. Further, assuming the wing blade as a homogeneous visco-elastic material, we have extended the model by assigning constant tension to the wing blade. Extending the model to a wider variety of insect wing margin shapes, we have inferred the bending stiffness of such margins and constructed a simple hybrid model of wing margin and blade by using the cell vertex model (with Dr. Sugimura).
As a cell-based model to realise viscoelastic dynamics of a tissue/organ-sized object, we have constructed the bubbly vertex model. Based on its implication, we have studied mouse olfactory system and its patterning dynamics (with Dr. Togashi et al.). Also, we have quantified the deformation of mouse tooth germ organogenesis (with Dr. Tsuji et al.).
We have submitted four papers to academic journals, three of which had been published by the end of the period.
|
Report
(4 results)
Research Products
(30 results)
-
[Journal Article] Coordination of cellular dynamics contributes to tooth epithelium deformations.2016
Author(s)
Morita, R., Kihara, M., Nakatsu, Y., Nomoto, Y., Ogawa, M., Ohashi, K., Mizuno, K., Tachikawa, T., Ishimoto, Y., Morishita, Y., and Tsuji, T.
-
Journal Title
PLoS One
Volume: 11
Issue: 9
Pages: 1-20
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
