| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Ionizing radiation and inside or outside stress induced in our body result in a increased ROS production and a induction of DNA double-strand breaks in the cells. A hypoxia caused by cerebral ischemia or glaucoma, nuclear foci formation by DNA double-strand breaks is also reported. A sensor of DNA damage foci formation using EGFP-53BP1 fusion protein makes DNA damage formation visible in the living mouse neuronal tissues or cells. As a result of our research, there is a clear difference of foci formation between differentiated tissue in vivo and culture cells in vitro, suggesting there exist special characteristics of foci formation and DNA damage response in the differentiated tissue cells.
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