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Influences on structure and metabolism of the myocardium in descendant mice after the every generational low dose-rate internal 137Cs radiation exposure

Research Project

Project/Area Number 26550039
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation and chemicals
Research InstitutionOsaka University

Principal Investigator

Nakajima Hiroo  大阪大学, 医学(系)研究科(研究院), 助教 (20237275)

Co-Investigator(Kenkyū-buntansha) YOSHIMURA Takashi  大阪大学, ラジオアイソトープ総合センター, 教授 (90323336)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords福島原発事故 / セシウム137 / 内部被ばく影響 / 心筋 / チェルノブイリ原発事故 / 酸化ストレス / 透過電顕解析 / メタボローム解析
Outline of Final Research Achievements

To investigate the structural and metabolic effects on the myocardium in descendant mice after the every generational low dose-rate internal 137Cs radiation exposure, every generations of mice were maintained in the radioisotope facility with free access to drinking water containing 137CsCl (100 Bq/ml). Mice(12 months of age) of the seventeenth generation were assessed metabolic analysis in heart, and the structure abnormality of the myocardium with the electron microscope, and were compared the influence between the offspring exposed to continuous low-dose radiation and control mice of the same generation that started from a littermate mouse.
Tendency to swelling of myocardium mitochondria and suppression of the glutathione level (p=0.033) and glycolytic pathway (nonsignificant) were observed in 137Cs drinking mice.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (20 results)

All 2015 2014

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 3 results) Book (4 results)

  • [Journal Article] Fukushima simulation experiment: Assessing the effects of chronic low-dose internal 137Cs radiation exposure on litter size, sex ratio, and biokinetics in mice.2015

    • Author(s)
      Hiroo Nakajima, Yoshiaki Yamaguchi, Takashi Yoshimura, Manabu Fukumoto and Takeshi Todo
    • Journal Title

      J Radiat Res

      Volume: 56

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Whack-A-Mole Model: Towards a Unified Description of Biological Effects Caused by Radiation Exposure.2015

    • Author(s)
      Yuichiro Manabe, Takahiro Wada, Yuichi Tsunoyama, Hiroo Nakajima, Issei Nakamura, and Masako Bando
    • Journal Title

      J. Phys. Soc. Jpn.

      Volume: 84 Pages: 044002-044002

    • NAID

      210000133505

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] インドにおける噛みタバコによる口腔がんの分子生物学的解析と予後予測2015

    • Author(s)
      本行忠志、 那波伸敏、中島裕夫、パリダ ディリップ
    • Journal Title

      日本臨床内科医会会誌

      Volume: 30 Pages: 401-401

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 放射線誘発突然変異頻度の線量・線量率応答への数理モデル―Whack-A-Moleモデル―の適用2015

    • Author(s)
      真鍋勇一郎, 和田隆宏, 中村一成, 角山雄一, 中島裕夫, 坂東昌子
    • Journal Title

      放射線生物研究

      Volume: 50 Pages: 211-225

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LNT再考 放射線の生体影響を考える2014

    • Author(s)
      真鍋勇―郎、中村―成、中島裕夫、角山雄―、坂東昌子
    • Journal Title

      日本原子力学会誌

      Volume: 56 Pages: 705-708

    • NAID

      130007799691

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imaging plant leaves to determine changes in radioactive contamination status in Fukushima, Japan.2014

    • Author(s)
      Nakajima H, et al.
    • Journal Title

      Health Phys.

      Volume: 106(5) Issue: 5 Pages: 565-570

    • DOI

      10.1097/hp.0000000000000020

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] セシウム137 の慢性的経口摂取で多世代にわたり低線量・低線量率内部被ばくを続けた子孫マウスのゲノムへの影響2015

    • Author(s)
      中島裕夫、福本 学、藤堂剛
    • Organizer
      日本環境変異原学会 第44回大会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 放射線誘発突然変異頻度を定量評価可能な線量率をあらわに取り入れた数理モデル2015

    • Author(s)
      真鍋勇一郎、和田隆弘、角山雄一、中島裕夫、坂東昌子
    • Organizer
      日本遺伝学会 第87回大会
    • Place of Presentation
      仙台
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Physiological, genomic effects in descendant mice after the every generational low dose-rate internal 137Cs radiation exposure.2015

    • Author(s)
      2.Hiroo Nakajima, Yoshiaki Yamaguchi, Takashi Yoshimura, Manabu Fukumoto, Takeshi Todo.
    • Organizer
      ICRR2015 (国際放射線研究会議)
    • Place of Presentation
      Kyoto
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Whack-a-mole (WAM) model which we can estimate the biological effect caused by radiation-exposure2015

    • Author(s)
      3.Yuichiro Manabe1, Takahiro Wada, Yuichi Tsunoyama, Hiroo Nakajima, Issei Nakamura, Masako Bando.
    • Organizer
      ICRR2015 (国際放射線研究会議)
    • Place of Presentation
      Kyoto
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Combined effects of radiation and chemicals; radiation-induced germ-line alteration causes cancer by postnatally-given chemicals2015

    • Author(s)
      4.Taisei Nomura, Li Ya Li, Tadashi Hongyo, Hiroo Nakajima, Shigeki Adachi, Haruko Ryo
    • Organizer
      ICRR2015 (国際放射線研究会議)
    • Place of Presentation
      Kyoto
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 福島シミュレーション実験としての137Csのマウス多世代低線量率内部被曝による子孫での突然変異の蓄積性2014

    • Author(s)
      中島裕夫、山口喜朗、吉村 崇、福本 学、藤堂剛
    • Organizer
      日本環境変異原学会第43回大会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 福島シミュレーション実験としての137Cs多世代慢性的経口摂取による低線量率内部被曝の子孫マウスへの影響2014

    • Author(s)
      中島裕夫、尾崎清和、岡幸子、福本学、藤堂剛
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 数理モデルによる突然変異発生頻度の統一的理解2014

    • Author(s)
      真鍋勇一郎、中村一成、中島裕夫、角山雄一、坂東昌子
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 産業廃棄物を利用した安価な放射能除去効果の立証と水溶液散布による放射能汚染土壌の線量低減効果のその後2014

    • Author(s)
      國分秀博、福谷泰雄、久保良喜、井阪尚司、浅井満来雄、中島裕夫、本行忠志、菊池潮美
    • Organizer
      環境放射能除染学会第3回大会
    • Place of Presentation
      広島市
    • Year and Date
      2014-09-16
    • Related Report
      2014 Research-status Report
  • [Presentation] 産業廃棄物を利用した安価な放射能除去と鉄資源再利用のシステム2014

    • Author(s)
      國分秀博、福谷泰雄、中島裕夫、久保良喜、井阪尚司、浅井満来雄
    • Organizer
      廃棄物資源循環学会第25回大会
    • Place of Presentation
      福島県郡山市
    • Year and Date
      2014-07-03
    • Related Report
      2014 Research-status Report
  • [Book] Fukushima Nuclear Accident: Global Implications, Long-Term Health Effects and Ecological Consequences2015

    • Author(s)
      Shizuyo Sutou, Hiroo Nakajima, et al.
    • Total Pages
      257
    • Publisher
      Nova Science Publishers
    • Related Report
      2015 Annual Research Report
  • [Book] 命を守る生体の機構と科学2015

    • Author(s)
      伊勢川裕二, 中島裕夫, 他
    • Total Pages
      221
    • Publisher
      武庫川女子大学出版部
    • Related Report
      2015 Annual Research Report
  • [Book] 放射線必須データ32-被ばく影響の根拠-2015

    • Author(s)
      中島裕夫、田中司郎、角山雄一、坂東昌子、他
    • Total Pages
      248
    • Publisher
      創元社
    • Related Report
      2015 Annual Research Report
  • [Book] 福島原発事故による周辺生物への影響に関する専門研究会報告書2015

    • Author(s)
      今中哲二、福本学、中島裕夫、他
    • Total Pages
      135
    • Publisher
      京大原子炉研究所
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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