Resistant Mechanism of Pollutants in Marine Organisms Suffered from Environmental Pollution by the Great East Japan Earthquake

• Project/Area Number: 26550083
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental risk control and evaluation
• Research Institution: Prefectural University of Kumamoto (2015-2016); Ehime University (2014)
• Principal Investigator: Agusa Tetsuro 熊本県立大学, 環境共生学部, 准教授 (50403853)
• Research Collaborator: Hirano Masashi ; Miyazaki Kohei ; Ban Masahiro ; Koike Miyuki ; Itoh Shohei
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 集団遺伝学的影響 / 生体毒性 / 東日本大震災 / 重油汚染 / PAH / メタゲノム / 気仙沼湾 / 遺伝毒性

Outline of Final Research Achievements

The present study investigated population genetic effects of polycyclic aromatic hydrocarbons (PAHs) on marine ecosystem in Kesennuma Bay affected by the Great East Japan Earthquake followed by heavy oil pollution. A bacterial flora analysis in marine sediments from Kesennuma Bay revealed that Rhodococcus, which has characters of oil resistant and decomposing, was highly distributed in the high PAHs contaminated areas. Since 2011, the abundance of Rhodococcus decreased year by year. These results suggest that Rhodococcus preferentially existed in heavy oil polluted areas and abundant of Rhodococcus decrease with decomposing and decreasing heavy oil.

Research Products

• [Journal Article] Strain differences in the proteome of dioxin-sensitive and -resistant mice treated with 2,3,7,8-tetrabromodibenzo-p-dioxin (2017)
  • Author(s): Nguyen, H.T., Lauan Tsuchiya, M.C., Yoo, J., Iida, M., Agusa, T., Hirano, M., Kim, E.-Y., Miyazaki, T., Nose, M., Iwata, H.
  • Journal Title: Archives of Toxicology Volume: 4 Issue: 4 Pages: 1763-1782
  • DOI: 10.1007/s00204-016-1834-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lead contamination in surface soil on roads from used lead-acid battery recycling in Northern Vietnam (2016)
  • Author(s): Fujimori, T., Eguchi, A., Agusa, T., Tue, N. M., Suzuki, G., Takahashi, S., Viet, P. H., Tanabe, S. and Takigami, H.
  • Journal Title: Journal of Material Cycles and Waste Management Volume: 18(4) Issue: 4 Pages: 599-607
  • DOI: 10.1007/s10163-016-0527-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification of aryl hydrocarbon receptor signaling pathways altered in TCDD- treated red seabream embryos by transcriptome analysis (2016)
  • Author(s): Midori Iida, Satoshi Fujii, Masaya Uchida, , Hiroshi Nakamura, Yoshihiro Kagami, Tetsuro Agusa, Masashi Hirano, Su-Min Bak, Eun-Young Kim, Hisato Iwata
  • Journal Title: Aquatic Toxicology Volume: 177 Pages: 156-170
  • DOI: 10.1016/j.aquatox.2016.05.014
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Lead Contamination in Surface Soil on Roads from Used Leaｄ-Acid Battery Recycling in Northern Vietnam (2016)
  • Author(s): Takashi Fujimori, Akifumi Eguchi, Tetsuro Agusa, Nguyen Minh Tue, Go Suzuki, Shin Takahashi, Pham Hung Viet, Shinsuke Tanabe, Hidetaka Takigami
  • Journal Title: Journal of Material Cycles and Waste Management Volume: in press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Haptoglobin genotyping of Vietnamese: global distribution of HPdel, complete deletion allele of the HP gene. (2015)
  • Author(s): Soejima M, Agusa T, Iwata H, Fujihara J, Kunito T, Takeshita H, Lan VT, Minh TB, Takahashi S, Trang PT, Viet PH, Tanabe S, Koda Y.
  • Journal Title: Legal Medicine Volume: 17 Issue: 1 Pages: 14-16
  • DOI: 10.1016/j.legalmed.2014.08.004
  • Peer Reviewed
• [Journal Article] In vitro and in silico analyses for predicting hepatic cytochrome p450-dependent metabolic potencies of polychlorinated biphenyls in the Baikal seal (2015)
  • Author(s): Jean Yoo, Masashi Hirano, Hazuki Mizukawa, Kei Nomiyama, Tetsuro Agusa, Eun-Young Kim, Shinsuke Tanab, Hisato Iwata
  • Journal Title: Environmental Science and Technology Volume: 49 Issue: 24 Pages: 14588-14596
  • DOI: 10.1021/acs.est.5b03890
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationship between Arsenic (+3 Oxidation State) Methyltransferase Genetic Polymorphisms and Methylation Capacity of Inorganic Arsenic (2015)
  • Author(s): 阿草哲郎, 國頭 恭, Nguyen Minh Tue, Vi Thi Mai Lan, Tu Binh Minh, Pham Thi Kim Trang, 藤原純子, 竹下治男, 高橋 真, Pham Hung Viet, 田辺信介, 岩田久人
  • Journal Title: Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) Volume: 70 Issue: 3 Pages: 186-196
  • DOI: 10.1265/jjh.70.186
  • NAID: 130005098973
  • ISSN: 0021-5082, 1882-6482
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Exposure assessment of lead to workers and children in the battery recyclingcraft village, Dong Mai, Vietnam. (2014)
  • Author(s): Noguchi T, Itai T, Tue NM, Agusa T, Ha NN, Horai S, Trang PTK, Viet PH, Takahashi s, Tanabe S.
  • Journal Title: Journal of Material Cycles and Waste Management Volume: 16 Issue: 1 Pages: 46-51
  • DOI: 10.1007/s10163-013-0159-0
  • Peer Reviewed
• [Journal Article] Human exposure to arsenic from drinking water in Vietnam (2014)
  • Author(s): Agusa, T., Trang, P. T. K., Lan, V. M., Anh, D. H., Tanabe, S., Viet, P. H. and Berg, M.
  • Journal Title: Science of the Total Environment Volume: in press Pages: 562-569
  • DOI: 10.1016/j.scitotenv.2013.10.039
  • Peer Reviewed
• [Journal Article] 慢性ヒ素曝露は寄生虫の薬剤耐性をもたらす (2014)
  • Author(s): 阿草哲郎
  • Journal Title: ファルマシア Volume: 50 Pages: 696-697
  • NAID: 130005245939
  • Peer Reviewed
• [Presentation] Arsenic Pollution in Southeast Asia (2017)
  • Author(s): Agusa, T., Nakata, H., Iwata, H., Tanabe, S.
  • Organizer: Japan - Taiwan International Symposium on Environmental Science, Technology and Management
  • Place of Presentation: 北九州
  • Year and Date: 2017-03-30
  • Int'l Joint Research / Invited
• [Presentation] Water pollution by trace elements in Myanmar (2016)
  • Author(s): Murakami, R., Omagari, R., Uchiyama, Y., Nakata, H., Phay, N., Agusa, T.
  • Organizer: Third Myanmar-Japan International Symposium
  • Place of Presentation: Pathein, Myanmar
  • Year and Date: 2016-12-03
  • Int'l Joint Research
• [Presentation] Trace elements in groundwater after The 2016 Kumamoto Earthquakes (2016)
  • Author(s): Kimura, N., Murakami, R., Ishii, E., Hashioto, M., Uchiyama, Y., Hosono, T., Nakata, H., Agusa, T.
  • Organizer: Third Myanmar-Japan International Symposium
  • Place of Presentation: Pathein, Myanmar
  • Year and Date: 2016-12-03
  • Int'l Joint Research
• [Presentation] メタボローム解析を用いたベトナムの地下水ヒ素汚染地域住民の影響評価：第2報 (2016)
  • Author(s): 阿草哲郎, 江口哲史, 國頭 恭, Tue, N.M., Lan, V.T.M., Minh, T.B., Trang, P.T.K., 高橋 真, Viet, P.H., 田辺信介, 岩田久人
  • Organizer: 第22回ヒ素シンポジウム
  • Place of Presentation: 江東区
  • Year and Date: 2016-11-17
  • Int'l Joint Research
• [Presentation] Contamination by trace elements associated with e-waste recycling processes in developing countries (2016)
  • Author(s): Agusa, T., Takigami, H., Fujimori, T., Eguchi, A., Bekki, K., Yoshida, A., Terazono, A., Ha, N.N., Asante, K.A., Biney, C.A., Agyekum, W.A., Bello, M., Ramu, K., Ballesteros Jr., F.C., Bulbule, K.A., Parthasaraty, P., Takahashi, S., Subramanian, A., Iwata, H., Tanabe, S.
  • Organizer: 2016 1st Eastern Asia Conference for Sustainable Economy (EACSE)
  • Place of Presentation: Taoyuan, Taiwan
  • Year and Date: 2016-09-26
  • Int'l Joint Research
• [Presentation] Mercury pollution at small-scale gold mining and e-waste recycling areas in Indonesia (2016)
  • Author(s): Hayama, S., Uchiyama, Y., Sudaryanto, A., Yoshida, A., Oguchi, M., Terazono, A., Skandarl, Tanabe, A., Agusa, T.
  • Organizer: Taiwan-Japan International Symposium on Environmental Science
  • Place of Presentation: Taoyuan, Taiwan
  • Year and Date: 2016-09-26
  • Int'l Joint Research
• [Presentation] Urgent survey on groundwater pollution caused by The 2016 Kumamoto Earthquakes (2016)
  • Author(s): Kimura, N., Murakami, R., Ishii, E., Hashioto, M., Uchiyama, Y., Hosono, T., Nakata, H., Agusa, T.
  • Organizer: Taiwan-Japan International Symposium on Environmental Science
  • Place of Presentation: Taoyuan, Taiwan
  • Year and Date: 2016-09-26
  • Int'l Joint Research
• [Presentation] Chemical pollution in water environment in Myanmar (2016)
  • Author(s): Murakami, R., Omagari, R., Uchiyama, Y., Nakata, H., Phay, N., Agusa, T.
  • Organizer: Taiwan-Japan International Symposium on Environmental Science
  • Place of Presentation: Taoyuan, Taiwan
  • Year and Date: 2016-09-26
  • Int'l Joint Research
• [Presentation] ベトナムの地下水ヒ素汚染とヒトへの曝露 (2016)
  • Author(s): 阿草哲郎
  • Organizer: 環境毒性化学とメダカに関する研究会 around 九州
  • Place of Presentation: 熊本
  • Year and Date: 2016-09-12
  • Int'l Joint Research
• [Presentation] メタボロミクスを用いたヒ素汚染地域住民の影響評価 (2016)
  • Author(s): 阿草哲郎, 江口哲史, Tue, N.M., Lan, V.T.M., Minh, T.B., Trang, P.T.K., 高橋 真, Viet, P.H., 田辺信介, 岩田久人
  • Organizer: 第25回環境化学討論会
  • Place of Presentation: 新潟
  • Year and Date: 2016-06-08
  • Int'l Joint Research
• [Presentation] 無機ヒ素の代謝に関与する遺伝子多型 (2016)
  • Author(s): 阿草哲郎, 國頭 恭, Nguyen Minh Tue, Vi Thi Mai Lan, Tu Binh Minh, Pham Thi Kim Trang, 藤原純子, 竹下治男, 高橋 真, Pham Hung Viet, 田辺信介, 岩田久人
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: 神奈川県横浜市西区みなとみらい
  • Year and Date: 2016-03-26
  • Invited
• [Presentation] My history of sampling and investigations of contamination by trace elements and their effects in Asian developing countries (2016)
  • Author(s): Tetsuro Agusa
  • Organizer: International Symposium on Environmental Chemistry and Toxicology – To Accelerate A Global Network of Environmental Researchers
  • Place of Presentation: 愛媛県松山市文京町
  • Year and Date: 2016-03-19
  • Int'l Joint Research
• [Presentation] メコン川および紅河流域における地下水のヒ素汚染 (2016)
  • Author(s): 阿草哲郎, 岩田久人, 井上 英, Karri Ramu, Nguyen Minh Tue, 田辺信介, 國頭 恭, 久保田領志, Tu Binh Minh, Pham Thi Kim Trang, Pham Hung Viet, Nguyen Ngoc Ha, Nguyen Phuc Cam Tu, Bui Cach Tuyen, Paromita Charaborty, Chhoun Chamnan, Alissara Reungsang, Kriengsak Srisuk, 中村 哲, 滝沢 智, 高橋 真, Annamalai Subramanian他
  • Organizer: 第50回日本水環境学会
  • Place of Presentation: 徳島県徳島市山城町
  • Year and Date: 2016-03-16
• [Presentation] Arsenic exposure and arsenic methylation capacity in residents of Asian countries (2016)
  • Author(s): Tetsuro Agusa, Hisato Iwata, Shinsuke Tanabe
  • Organizer: International Symposium on Environment and Resource Recycling Technology 2016
  • Place of Presentation: 宮崎県宮崎市学園木花台西
  • Year and Date: 2016-03-04
  • Int'l Joint Research / Invited
• [Presentation] アジア途上国の微量元素汚染とその影響 (2016)
  • Author(s): 阿草哲郎
  • Organizer: 福岡県保健環境研究所集談会
  • Place of Presentation: 福岡県太宰府市大字向佐野
  • Year and Date: 2016-01-28
  • Invited
• [Presentation] Brief introduction of studies on contamination by metals in Asian countries (2016)
  • Author(s): Tetsuro Agusa
  • Organizer: First Workshop on Indoor Air Pollution and Advanced Air Pollution Control Technologies
  • Place of Presentation: 熊本県熊本市東区月出
  • Year and Date: 2016-01-08
  • Int'l Joint Research / Invited
• [Presentation] Contamination by arsenic and other trace elements in groundwater from the Red and Mekong River Deltas (2015)
  • Author(s): Tetsuro Agusa, Hisato Iwata, Takashi Kunito, Suguru Inoue, Reiji Kubota, Karri Ramu, Tu Binh Minh, Nguyen Minh Tue, Nguyen Ngoc Ha, Nguyen Phuc Cam Tu, Paromita Charaborty, Chhoun Chamnan, Pham Thi Kim Trang, Alissara Reungsang, Kriengsak Srisuk, Satoshi Nakamura, Satoshi Takizawa, Shinsuke Tanabe他
  • Organizer: The Second Myanmar-Japan Symposium
  • Place of Presentation: Pathein, Myanmar
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] メタボローム解析を用いたベトナムの地下水ヒ素汚染地域住民の影響評価 (2015)
  • Author(s): 阿草哲郎, 江口哲史, 國頭 恭, Tue, N.M., Lan, V.T.M., Minh, T.B., Trang, P.T.K., 高橋 真, Viet, P.H., 田辺信介, 岩田久人
  • Organizer: 第21回ヒ素シンポジウム
  • Place of Presentation: 徳島県徳島市山城町
  • Year and Date: 2015-11-14
• [Presentation] Metallomics of wildlife: the mechanism of mercury detoxification in higher trophic marine animals (2015)
  • Author(s): Tetsuro Agusa, Shin-ya Yasugi, Tokutaka Ikemoto, Takashi Kunito, Shinsuke Tanabe, Hisato Iwata
  • Organizer: The 3rd Sapporo Summer Seminar for One Health (SaSSOH)
  • Place of Presentation: 北海道札幌市北区
  • Year and Date: 2015-09-16
  • Int'l Joint Research / Invited
• [Presentation] Arsenic exposure in residents from arsenic-contaminated groundwater areas of Southeast Asia (2015)
  • Author(s): Tetsuro Agusa, Takashi Kunito, Reiji Kubota, Shinsuke Tanabe, Hisato Iwata
  • Organizer: ASIATOX2015 (The 7th International Congress of Asian Society of Toxicology)
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2015-06-23
  • Int'l Joint Research / Invited
• [Presentation] ベトナムにおける地下水のヒ素、マンガン、バリウム汚染とヒトの健康リスク (2015)
  • Author(s): 阿草哲郎, 國頭 恭, 井上 英, Minh Tu Binh, Tue Nguyen Minh, Ha Nguyen Ngoc, Tu Nguyen Phuc Cam, Trang Pham Thi Kim, 高橋真, Tuyen Bui Cach, Viet Pham Hung, 岩田久人, 田辺信介
  • Organizer: 日本地球惑星科学連合2015年大会
  • Place of Presentation: 千葉県千葉市美浜区
  • Year and Date: 2015-05-24
  • Invited
• [Presentation] Relationship between mRNA expression level and SNPs of AS3MT in residents from arsenic-contaminated areas in Vietnam (2015)
  • Author(s): Agusa, T., Kunito, T., Tue, N.M., Lan, V.T.M., Minh, T.B., Trang, P.T.K., Fujihara, J., Takeshita, H., Takahashi, S., Viet, P.H., Tanabe, S., Iwata, H.
  • Organizer: The Society of Toxicology (SOT) 54th Annual Meeting
  • Place of Presentation: San DIego Convention Center・USA・CA・San Diego, 111 West Harbor Drive
  • Year and Date: 2015-03-25
• [Presentation] ウミガメ類におけるヒ素化合物の蓄積特性 (2014)
  • Author(s): 阿草哲郎, 高木 梢, Todd W Miller, 久保田領志, 阿南弥寿美, 岩田久人, 田辺信介
  • Organizer: 第20回ヒ素シンポジウム
  • Place of Presentation: 千葉科学大学マリーナキャンパス・千葉県・銚子市潮見町15－8
  • Year and Date: 2014-12-06
• [Presentation] 海棲高等動物はどのように水銀を解毒しているのか？ (2014)
  • Author(s): 阿草哲郎, 安木進也, 池本徳孝, 國頭 恭, 馬場徳寿, 田辺信介, 岩田久人
  • Organizer: 第33回生体と金属・化学物質に関する研究会（チョークトーク2014）
  • Place of Presentation: KKR江ノ島ニュー向洋・神奈川県・藤沢市片瀬海岸1-7-23
  • Year and Date: 2014-08-21
• [Presentation] 海棲哺乳類の肝臓におけるHg結合タンパク質 (2014)
  • Author(s): 阿草哲郎, 安木進也, 池本徳孝, 國頭 恭, 馬場徳寿, 田辺信介, 岩田久人
  • Organizer: 第25回日本微量元素学会
  • Place of Presentation: 岡山大学創立五十周年記念館・岡山県・岡山市北区津島中1-1-1
  • Year and Date: 2014-07-03
• [Presentation] AS3MT遺伝子多型と無機ヒ素のメチル化能力との関係 (2014)
  • Author(s): 阿草哲郎, 國頭 恭, Nguyen Minh Tue, Vi Thi Mai Lan, Tu Binh Minh, Pham Thi Kim Trang, 藤原純子, 竹下治男, 高橋 真, Pham Hung Viet, 田辺信介, 岩田久人
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター・岡山県・岡山市北区駅元町14-1
  • Year and Date: 2014-05-25
  • Invited
• [Presentation] キタオットセイ（Callorhinus ursinus）の肝臓における水銀結合タンパク質の探索 (2014)
  • Author(s): 阿草哲郎, 安木進也, 池本徳孝, 國頭 恭, 馬場徳寿, 田辺信介, 岩田久人
  • Organizer: 第23回環境化学討論会
  • Place of Presentation: 京都大学百周年記念時計台記念館、芝蘭会館、芝蘭会館別館・京都府・京都市左京区吉田本町
  • Year and Date: 2014-05-16
• [Book] Arsenic Toxicity: Prevention and Treatment (2015)
  • Author(s): Tetsuro Agusa
  • Total Pages: 508
  • Publisher: CRC Press/Taylor & Francis
• [Book] Arsenic Toxicity : Prevention and Treatment (2015)
  • Author(s): Agusa, T
  • Total Pages: 113
  • Publisher: CRC Press/Taylor & Francis