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Materials Design for Safety Foods

Research Project

Project/Area Number 26560041
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionUniversity of Tsukuba

Principal Investigator

Nagasaki Yukio  筑波大学, 数理物質系, 教授 (90198309)

Co-Investigator(Kenkyū-buntansha) 松井 裕史  筑波大学, 医学医療系, 講師 (70272200)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords放射線滅菌 / ポストハーベスト / 活性酸素種 / 酸化ストレス / 活性酸素 / 安定ラジカル / レドックスポリマー / リステリア菌 / 感染症
Outline of Final Research Achievements

The globalization of food distribution has made it difficult for a single country to achieve food safety by itself. For example, post-harvest treatments of fruits and vegetables may loose our health although they are prohibited in our country. In order to improve new technologies on these issues, we have tried to develop new system by our newly designed materials. We have been investigating on design of new polymers and nanoparticles with possess elimination activity of reactive oxygen species (ROS). In this work have confirmed safety of our materials using zebra fish embrio. Using our redox-active polymer nanoparticles, we have also investigated protective effect of meats from radiation sterilization treatments. On the basis of these investigations, we have confirmed that our redox polymer nanoparticles prevented radiation damage of meat and suppression of bacterial infection effectively.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2015

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 5 results,  Invited: 5 results) Book (1 results)

  • [Journal Article] A Novel Nitric Oxide-based Anticancer therapeutics by Macrophage-targeted Poly(L-Arginine)-based Nanoparticles2015

    • Author(s)
      Shinpei Kudo, Yukio Nagasaki
    • Journal Title

      Journal of Controlled Release

      Volume: 217 Pages: 256-262

    • DOI

      10.1016/j.jconrel.2015.09.019

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific accumulation of orally administered redox nanotherapeutics in the inflamed colon reducing inflammation with dose-response efficacy2015

    • Author(s)
      Long Binh Vong, John Mo, Bertil Abrahamsson and Yukio Nagasaki
    • Journal Title

      Journal of Controlled Release

      Volume: 210 Pages: 19-25

    • DOI

      10.1016/j.jconrel.2015.05.275

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Redox nanoparticles inhibit curcumin oxidative degradation and enhance its therapeuc effect on prostate cancer2015

    • Author(s)
      Sindhu Thangavel, Toru Yoshitomi, Meena Kishore Sakharkar and Yukio Nagasaki
    • Journal Title

      Journal of Controlled Release

      Volume: 209 Pages: 110-119

    • DOI

      10.1016/j.jconrel.2015.04.025

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Design of high-performance anti-adhesion agent using injectable gel with an anti-oxidative stress function.2015

    • Author(s)
      Nakagawa H, Matsumoto Y, Matsumoto Y, Miwa Y, Nagasaki Y
    • Journal Title

      Biomaterials

      Volume: 69 Pages: 165-173

    • DOI

      10.1016/j.biomaterials.2015.08.018

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recovery of Cognitive Dysfunction via Orally Administered Redox-polymer Nanotherapeutics in SAMP8 mice2015

    • Author(s)
      Pennapa Chonpathompikunlert, Toru Yoshitomi, Long Binh Vong, Natsuka Imaizumi, Yuki Ozaki, Yukio Nagasaki
    • Journal Title

      PLOS ONE

      Volume: ー Issue: 5 Pages: e0126013-e0126013

    • DOI

      10.1371/journal.pone.0126013

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Silica-containing redox nanoparticles as nanokidney2015

    • Author(s)
      Yukio Nagasaki
    • Organizer
      Honolulu, Hawaii, U.S.A.
    • Place of Presentation
      Honolulu, Hawaii, U.S.A.
    • Year and Date
      2015-12-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Redox Injectable Gels for Local Inflammation Treatments2015

    • Author(s)
      Yukio Nagasaki
    • Organizer
      PachfiCem2015
    • Place of Presentation
      Honolulu, Hawai, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Nitric oxide -A key player for novel target of immunotherapeutics-2015

    • Author(s)
      Yukio Nagasaki
    • Organizer
      PachfiCem2015
    • Place of Presentation
      Honolulu, Hawaii, U.S.A.
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel Nanotherapeutics by Anti-oxidatie Nanomedicine2015

    • Author(s)
      Yukio Nagasaki
    • Organizer
      Biomaterials International
    • Place of Presentation
      Kenting, Taiwan
    • Year and Date
      2015-06-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel Anti-oxidative Nanotherapeutics2015

    • Author(s)
      Yukio Nagasaki
    • Organizer
      5th Asian Biomaterials Congress(ABMC5)
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-05-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] レドックスナノメディシンによる安全な抗酸化治療法の開発2015

    • Author(s)
      長崎幸夫
    • Total Pages
      200
    • Publisher
      医学のあゆみ
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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