Analysis of metabolite and food habit in preventing recurrence for liver cancer by metabolomics
| Project/Area Number |
26560056
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Eating habits
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
OKUMURA Hisami 徳島大学, 大学院医歯薬学研究部, 講師 (30322259)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 食生活 / 肝疾患 / メタボロミクス / 栄養学 / メタボローム解析 / 肝癌 / 食習慣 |
|---|
| Outline of Final Research Achievements |
Metabolome analysis can make metabolite and metabolic pathway understand clearly. Perioperative nutritional management is an important for early recovery after surgery. Patients with hepatocellular carcinoma were recruited in this study. Serum and spot urine were collected before and post operative days of hepatectomy. Metabolites in serum and urine were analysed by capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS). At POD3, serum BCAA levels did not change and AAA significantly increased, so Fischer ratio significantly decreased after liver resection.
Metabolome analyses to assess both serum and urine were useful for evaluation of metabolite accurately.
|
Report
(3 results)
Research Products
(10 results)
