| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
This study aimed to reveal the extent to which the nutritional environment of the mother during pregnancy influences that of the fetus. Focusing on amniotic fluid, two experiments were performed to obtain insight into the effects of maternal nutritional status on nutrient transport to the fetus: Experiment (1), involving pregnant rats fed a low-carbohydrate, high-fat diet (KD), and Experiment (2), involving an analysis of nutrient-derived components in the blood, urine ((1) only) and amniotic fluid of pregnant women (rats). Sample concentrations of glucose, ketone bodies, free amino acids ((2) only), Tryptophan ((1) only), NAD, folic acid, and vitamin B12 were measured. Pregnant women were administered a food survey in addition. In Experiment (1), ketone body levels in mother and fetuses and conversion ratio of Tryptophan to Niacin in mothers rose in KD group. This finding demonstrated that maternal ketotic state affects the fetus. Experiment (2) is still under investigation.
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