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Analysis of the changes in the intestinal flora and the effects on the homeostasis caused by food additive nanoparticles

Research Project

Project/Area Number 26560066
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionOsaka Prefecture University

Principal Investigator

Tokumoto Hayato  大阪府立大学, 工学(系)研究科(研究院), 講師 (70405348)

Co-Investigator(Kenkyū-buntansha) 木下 卓也  関西大学, 環境都市工学部, 准教授 (90453141)
星 英之  大阪府立大学, 人間社会システム科学研究科, 准教授 (30301188)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords腸内細菌 / 菌叢解析 / 嫌気発酵 / ナノ粒子 / 粒径 / 食品添加物 / マウス / 経口投与 / 菌叢
Outline of Final Research Achievements

Development of nanoparticle (NP) production have resulted in the appearance of numerous food additive NPs in the market. However, there are concerns about the risks of consuming these NPs.In this research, to study the effects of these NPs on the intestinal flora, three types of NPs, namely, anatase TiO2 NPs with a nominal particle size of 0.5μm, SiO2 NPs with a nominal particle size of 0.8μm, and Fe2O3 NPs with a nominal particle size of 0.3μm were orally administered to mice, and the feces excreted were analyzed for intestinal flora.From the result indicate that,excessive consumption of soluble food additive NPs with a small particle size cause great changes in the composition of the intestinal flora, and there is a risk that these could lead to digestive tract disorders because of the increasing predominance of Clostridiaceae species.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Invited: 3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Value-adding conversion and volume reduction of sewage sludge by anaerobic co-digestion with crude glycerol2017

    • Author(s)
      K. Kurahashi, C. Kimura, Y. Fujimto, H. Tokumoto
    • Journal Title

      Bioresource Technology

      Volume: 232 Pages: 119-125

    • DOI

      10.1016/j.biortech.2017.02.012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 食品添加物粒子が腸内細菌叢に与える影響2017

    • Author(s)
      徳本勇人,野村俊之,星 英之,新居靖崇,大谷俊晴,野本健太
    • Journal Title

      粉体工学会誌

      Volume: 54 Pages: 172-177

    • NAID

      130005606222

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Fe2O3ナノ粒子が腸内細菌叢に与える影響の解析2016

    • Author(s)
      新居靖崇,木岡 真理奈,武藤明徳,徳本勇人
    • Organizer
      化学工学会第48回秋季大会
    • Place of Presentation
      徳島大学(徳島市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] TiO2ナノ粒子が腸内細菌叢に与える影響の解析2016

    • Author(s)
      木岡 真理奈,新居靖崇,武藤明徳,徳本勇人
    • Organizer
      化学工学会第48回秋季大会
    • Place of Presentation
      徳島大学(徳島市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 食品添加物ナノ粒子がマウスの腸内細菌叢に与える影響の解析2016

    • Author(s)
      徳本勇人,星 英之,新居靖崇,大谷俊晴,岡野凌一,木岡 真理奈
    • Organizer
      粉体工学会第52回夏期シンポジウム
    • Place of Presentation
      ひょうご共済会館(神戸市)
    • Year and Date
      2016-08-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 食品ナノ粒子が腸内細菌に付着して起こる菌叢変化の解析2016

    • Author(s)
      徳本勇人
    • Organizer
      粉体工学会2016年度春期研究発表会
    • Place of Presentation
      京都リサーチパーク(京都市)
    • Year and Date
      2016-05-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] アサギマダラ幼虫の腸内細菌叢の解析2016

    • Author(s)
      岡野凌一,新居靖崇,倉橋健介,徳本勇人,石井 実,平井規央
    • Organizer
      日本昆虫学会第76回大会・第60回日本応用動物昆虫学会大会合同大会
    • Place of Presentation
      大阪府立大学(大阪府堺市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 地域と環境-新たなバイオエネルギー利活用法の探索の取り組みから-2016

    • Author(s)
      徳本勇人
    • Organizer
      大阪府立大学授業公開講座
    • Place of Presentation
      大阪府立大学(大阪府堺市)
    • Year and Date
      2016-01-28
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 大阪府立大学におけるバイオマス利活用事例2016

    • Author(s)
      徳本勇人
    • Organizer
      平成28年度日本粉体工業技術協会・食品粉体技術分科会・湿式プロセス分科会合同分科会
    • Place of Presentation
      あべのハルカス(大阪市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] バイオガス発電の可能性と府立大学でのバイオガス利用事例2015

    • Author(s)
      徳本勇人
    • Organizer
      日報ビジネス2015秋の関西セミナーウィーク
    • Place of Presentation
      大阪産業創造館(大阪府大阪市)
    • Year and Date
      2015-10-14
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 食品添加物ナノ粒子がマウスの腸内細菌叢に与える影響の解析2015

    • Author(s)
      徳本勇人,星英之,野本健太,大谷俊晴,新居靖崇
    • Organizer
      環境バイオテクノロジー学会2015年度大会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2015-06-29
    • Related Report
      2015 Research-status Report
  • [Presentation] 放射性セシウム含有バイオマスの嫌気発酵処理技術の構築2015

    • Author(s)
      野本健太,村田森応,星英之,古田雅一,徳本勇人
    • Organizer
      環境バイオテクノロジー学会2015年度大会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2015-06-29
    • Related Report
      2015 Research-status Report
  • [Presentation] 金属ナノ粒子が動物の腸内細菌に与える影響の解析2014

    • Author(s)
      大谷俊晴、星英之、木下卓也、武藤明徳、徳本勇人
    • Organizer
      環境微生物系学会合同学会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2014-10-21 – 2014-10-24
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 植物細胞培養用の液体培地および植物細胞の培養方法2016

    • Inventor(s)
      徳本勇人、竹田恵美、吉原静恵、野村俊之、中島淑乃、山本花純
    • Industrial Property Rights Holder
      徳本勇人、竹田恵美、吉原静恵、野村俊之、中島淑乃、山本花純
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-155754
    • Filing Date
      2016-08-08
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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