| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
It has been shown that a fatigue could be caused by the inflammatory response of immune cells such as dendritic cells, macrophages and monocytes. In this study, the author has shown that both pro- and anti-inflammatory cytokines could become good bio-markers to diagnose fatigue. Moreover, some mushroom showed anti-inflammatory effect on the immune cells. And, the glucan from Pleurotus cornucopiae mushroom could suppress a differentiation of monocyte into inflamed macrophage despite the finding that the glucan induced to inflame matured dendritic cells, macrophages and monocytes. Therefore, this study has considered that some mushrooms can inhibit inflammation of immune cells, and prevent the fatigue.
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