| Project/Area Number |
26560071
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
kawai yuichi 神戸学院大学, 薬学部, 教授 (00102921)
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| Co-Investigator(Kenkyū-buntansha) |
ONODERA Akira 神戸学院大学, 薬学部, 助教 (40598380)
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| Research Collaborator |
NEZU Natsumi
IHIBASHI Takafumi
SHIMOBEPU Rina
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 亜鉛 / 腸管上皮 / トランスポーター / 亜鉛欠乏 / 亜鉛トランスポーター / 亜鉛輸送 |
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| Outline of Final Research Achievements |
The recommended consumption of zinc per day is approximately 5 mg for infants and 15 mg for children and adults. Zinc is absorbed from the intestine, and the amount of absorption is regulated by intestinal epithelial cells that express zinc transporters. Reduced function of zinc transporters is one of the reasons to cause the symptoms of zinc deficiency, and patients with a zinc deficiency are prescribed zinc in an amount that is approximately 6-10 times that of the recommended consumption per day. We thought that identification of ligands that can efficiently transport zinc could lead to treatments that may prevent and reduce symptoms of zinc deficiency. In this study, we identified three types of ligands that increased the uptake efficiency of intestinal epithelial cells, and a zinc complex that included these ligands was confirmed to be effective in treating obesity and osteoporosis associated with zinc deficiency in animal experiments.
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