| Project/Area Number |
26560077
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | National Fisheries University |
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Principal Investigator |
Usui Masakatsu 独立行政法人水産大学校, その他部局等, 准教授 (50399656)
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| Co-Investigator(Renkei-kenkyūsha) |
Azakami Hiroyuki 山口大学, 農学部, 教授 (40263850)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | エビアレルギー / トロポミオシン / 胃粘膜 / 急性胃炎 / 重篤化 / 感作 / 胃粘膜環境 |
|---|
| Outline of Final Research Achievements |
To investigate about a relation between deterioration of the gastric mucosa environment and allergy to shrimps, we prepared the shrimp allergy mouse model by 4 times of intra-gastric administration with cholera toxin. After gastritis induction by 25% ethanol administration, these model mice were challenged by receiving one intra-gastric dose of shrimp allergens. Production levels of shrimp allergen-specific IgE were higher than healthy gastric control mice group in gastritis mice group. In addition, the production levels of shrimp allergen-specific IgE in mice sensitized with gastritis induction showed the increased tendency compared to healthy mice.
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