| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Elucidation of the mechanical interaction between an erythrocyte and an endothelial cell is an important issue relating to mechanisms of cardiovascular diseases. The objective of this study was to clarify the mechanical interaction between an erythrocyte moving in medium subject to inclined centrifugal force and endothelial cells on a plate. Three-dimensional numerical simulation was performed with contact force models between an erythrocyte and glycocalyx on the surface of endothelial cells and two-dimensional analysis was conducted using a lubrication theory for compressible porous media and a simple erythrocyte model. In the 3D simulation, two contact force models were adopted in which shear stresses acting on the bottom surface of an erythrocyte varied proportional or inversely proportional to the distance to the base plate. As a result, the experimental frictional characteristics for an endothelia-cultured plate were properly reproduced by the inverse proportion model.
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