3D microstructure of actin stress fibers
| Project/Area Number |
26560208
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Osaka University (2016)
Nagoya Institute of Technology (2014-2015) |
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Principal Investigator |
Deguchi Shinji 大阪大学, 基礎工学研究科, 教授 (30379713)
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| Co-Investigator(Kenkyū-buntansha) |
上野 裕則 愛知教育大学, 教育学部, 准教授 (70518240)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUI Tsubasa 大阪大学, 大学院基礎工学研究科, 講師 (50638707)
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| Research Collaborator |
IMAMURA Michihiro 国立精神・神経医療研究センター, 神経研究所・遺伝子疾患治療研究部, 室長 (80221787)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ストレスファイバー / 焦点接着斑 / 非筋α-アクチニン / 細胞バイオメカニクス / メカノバイオロジー |
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| Outline of Final Research Achievements |
Stress fibers (SFs) are filamentous protein complexes present within nonmuscle cells. SFs have been implicated in various cellular functions including control of pro-inflammatory signaling, but as their 3D microstructure remains unclear, the molecular/physical mechanisms underlying the diverse functions remain to be elucidated. Here we isolated functional SFs to reveal a specific microstructure associated with nonmuscle alpha-actinin at the boundary between the individual SFs and focal adhesions that are located at the termini of the SFs.
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Report
(4 results)
Research Products
(37 results)
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[Presentation] 細胞が発生する力の評価2016
Author(s)
出口真次
Organizer
名市大・医・Department seminar
Place of Presentation
名古屋市立大学
Year and Date
2016-01-25
Related Report
Invited
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[Presentation] The effect of substrate curvature on myosin-based frictional slip and elongation of focal adhesions2015
Author(s)
Araki, T., Yokoyama, S., Matsui, T.S., Ohishi, T., Kato, K., Deguchi, S.
Organizer
2015 BMES Annual Meeting
Place of Presentation
Tampa Convention Center
Year and Date
2015-10-07
Related Report
Int'l Joint Research
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[Presentation] New cellular traction force microscopy reveals the effect of substrate curvature on focal adhesion dynamics2015
Author(s)
Deguchi, S., Yokoyama, S., Matsui, T.S., Kato, K., Araki, T., Ohishi, T.
Organizer
ATEM'15: International Conference on Advanced Technology in Experimental Mechanics 2015
Place of Presentation
ロジワールホテル豊橋
Year and Date
2015-10-04
Related Report
Int'l Joint Research
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[Presentation] Role of nonmuscle myosin regulatory light chain phosphorylation in contractile force generation2015
Author(s)
Deguchi, S., Yokoyama, S., Matsui, T.S., Kato, K., Araki, T., Ohishi, T., Kuragano, M., Takahashi, M.
Organizer
15th International Congress of Biorheology
Place of Presentation
韓国・高麗大学
Year and Date
2015-05-24
Related Report
Int'l Joint Research / Invited
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[Presentation] Load-dependent contractile force generation of actin stress fibers2014
Author(s)
Matsui, T.S., Sato, M., Deguchi, S.
Organizer
Matsui, T.S., Sato, M., Deguchi, S.
Place of Presentation
Shima Kanko Hotel The Classic (Shima)
Year and Date
2014-09-01 – 2014-09-09
Related Report
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