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Heart Tissue Engineering: Integration of microfabrication technology and THz wave

Research Project

Project/Area Number 26560209
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionKyoto University

Principal Investigator

Kamei Ken-ichiro  京都大学, 物質-細胞統合システム拠点, 特定拠点准教授 (00588262)

Co-Investigator(Renkei-kenkyūsha) 廣理 英基  京都大学, 物質-細胞統合システム拠点, 特定拠点准教授 (00512469)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords幹細胞 / マイクロ流体デバイス / THz / 組織工学 / 心筋細胞 / 細胞工学 / iPS細胞 / 顕微鏡 / テラヘルツ波 / ヒトES/iPS細胞 / 心筋 / 分化誘導 / 成熟化
Outline of Final Research Achievements

We aimed to develop a new platform to obtain functional and mature cardiomyocytes derived from human embryonic stem (ES) and induced pluripotent stem (iPS) cells by utilizing a microfluidic device in combination with THz wave. Specifically, A. to develop a microfluidic device allowing three-dimensional cell culture for cardiomyocytes, B. to combine the experimental setups of both THz microscope and microfluidic devices, C. to make mature cardiomyocytes by irradiating THz wave. Our devices would be very beneficial for regenerative medicine as well as drug screening for heart diseases.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Book (2 results)

  • [Journal Article] Microfluidic-nanofiber hybrid array for screening of cellular microenvironments2017

    • Author(s)
      K. Kamei, Y. Mashimo, M. Yoshioka, Y. Tokunaga, C. Fockenberg, S. Terada, M. Nakajima, T. Shibata-Seki, L. Liu, T. Akaike, E. Kobatake, E. S. How, M. Uesugi and Y. Chen
    • Journal Title

      Small

      Volume: 印刷中 Issue: 18 Pages: 1603104-1603104

    • DOI

      10.1002/smll.201603104

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 3次元微細加工を応用したBody on a Chip の開発2016

    • Author(s)
      加藤義基, 平井義和, 亀井謙一郎, 土屋智由, 田畑修
    • Journal Title

      電気学会論文誌(センサ・マイクロマシン部門誌)

      Volume: 136

    • NAID

      40020858740

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Directing and boosting of cell migration by the entropic force gradient in polymer solution2015

    • Author(s)
      T. Fukuyama, A. Fuke, M. Mochizuki, K. Kamei and Y. T. Maeda
    • Journal Title

      Langmuir

      Volume: 31 Issue: 46 Pages: 12567-12572

    • DOI

      10.1021/acs.langmuir.5b02559

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oscillation and collective conveyance of water-in-oil droplets by microfluidic bolus flow2015

    • Author(s)
      T. Ohnuma, M. Ichikawa, K. Kamei, Y. T. Maeda
    • Journal Title

      Applied Physics Letters

      Volume: 107 Issue: 7 Pages: 074102-074102

    • DOI

      10.1063/1.4928753

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Microfluidic device to interconnect multiple organs via fluidic circulation: Towards Body-on-a-Chip2015

    • Author(s)
      Y. Kato, Y. Hirai, K. Kamei, T. Tsuchiya, O. Tabata
    • Organizer
      The 18th International Conference on Solid-State Sensors Actuators and Microsystems (Transducers’15)
    • Place of Presentation
      Anchorage, AK, USA
    • Year and Date
      2015-06-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] Methods Mol. Biol.2015

    • Author(s)
      Y. Mashimo, K. Kamei
    • Total Pages
      14
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report
  • [Book] Methods in Molecular Biology2015

    • Author(s)
      Yasumasa Mashimo, Ken-ichiro Kamei
    • Publisher
      Springer
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2021-01-27  

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