| Project/Area Number |
26560215
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Research Collaborator |
TAMURA CHIHIRO
KATO NAO
KOBAYASHI RYOMA
SAKAI KIYOSHI
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 抗酸化物質 / イメージング |
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| Outline of Final Research Achievements |
Ascorbic acid is one of the major antioxidants and has been regarded to play multiple roles in antioxidant defense system, having both roles of pro- and anti- oxidant. It is thus important to investigate its reaction mechanism in vivo, for oxidative stress disease research.
In this study, an imaging approach with Overhauser enhanced MRI (OMRI) was developed for imaging ascorbic acid radical in mice. Magnetic resonance spectroscopic characterization of ascorbic acid radical was investigated and OMRI resonators were developed to maximize detection sensitivity for ascorbic acid radical. In results, ascorbic acid radical were imaged with OMRI after administration of the radical solution i.m., i.v., i.p. and s.c.
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