| Project/Area Number |
26560216
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IJIMA HIROYUKI 九州大学, 大学院工学研究院, 教授 (10274515)
MIZUMOTO HIROSHI 九州大学, 大学院工学研究院, 准教授 (90346817)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 生物・生体工学 / 細胞・組織 / バイオリアクター / 人工臓器工学 |
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| Outline of Final Research Achievements |
We have created genetically modified hepatoma cells (Super-hepatoma) with high liver functions, comparable to those of primary hepatocytes, by inducible overexpression of eight liver-specific transcription factors. To construct a bioartificial liver system using the Super-hepatoma, the cells were modified with a novel induction system for functionalization and the cell immobilization conditions were examined for fabrication of a bioartificial liver module.
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