| Project/Area Number |
26560223
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Shibaura Institute of Technology |
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Principal Investigator |
Yoshimi Yasuo 芝浦工業大学, 工学部, 教授 (30267421)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 分子インプリント高分子 / 分子認識 / セロトニン / バイオセンサ / グラフト重合 / 電子移動 / 神経 / 学習 / 神経伝達物質 / ブレインマシンインターフェイス / 味覚 / 微細電極 / リエージェントレス / 酸化電流 / 電気化学 / センサ / 神経インターフェイス |
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| Outline of Final Research Achievements |
We attempted a neurotransmitter-sensor using molecularly imprinted polymer (MIP) . Poly(Methacrylic acid-co-ethyleneglycoldimethacrylate-co-vynylferrocene) was grafted onto indium-tin oxide electrodes imprinted with serotonin. The differential current between the grafted electrodes imprinted or non-imprinted with serotonin was sensitive to serotonin with selectivity. The result indicated that pair of the imprinted and the non-imprinted electrodes are useful as a serotonin sensor. We also discovered S-cluster in Apllysia buccal ganglion response to taste stimulation with indicating learning. Then those results indicates that pair of the grafted electrodes implanted in the S-cluster of Aplysia would be helpful for development of a new model of brain-machine interface by detection of serotonin release regulated by learning of the animal for control of machine.
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