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Polymeric nanosheets for cell and drug delivery and in vivo local monitoring

Research Project

Project/Area Number 26560233
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionTohoku University

Principal Investigator

Kaji Hirokazu  東北大学, 工学(系)研究科(研究院), 准教授 (70431525)

Co-Investigator(Renkei-kenkyūsha) ISHIMURA KOSEI  独立行政法人宇宙航空研究開発機構, 宇宙科学研究所, 准教授 (10333626)
FUJIE TOSHINORI  早稲田大学, 理工学術院, 助教 (70538735)
NAGAMINE KUNIAKI  東北大学, 大学院工学研究科, 助教 (00551540)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords細胞・組織工学材料
Outline of Final Research Achievements

Multifunctional cell culture scaffolds consisting of flexible, ultrathin polymeric films (nanosheets) have been developed toward cell transplantation therapy for intractable retinal diseases such as age-related macular degeneration. Retinal pigment epithelial (RPE) cells cultured on biodegradable nanosheets formed a monolayer with hexagonal tight junctions found in native tissues. It is found that those cell/nanosheet composites can be aspirated and injected by a syringe needle without significant loss of cell morphology and viability. Also, the ability to release drugs and to sense oxygen and pH could be given to nanosheets by loading functionalized nanoparticles into nanosheets. The developed nanosheets would be expected as a biomedical device to support stem cell therapy.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (24 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (16 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Protective effects of transscleral sustained unoprostone delivery against retinal degeneration in S334ter rhodopsin mutant rats2015

    • Author(s)
      Nobuhiro Nagai, Satoru Iwata, Kaori Sampei, Hideyuki Onami, Hirokazu Kaji, Matsuhiko Nishizawa, Toru Nakazawa, Yukihiko Mashima, Toshiaki Abe
    • Journal Title

      Journal of Biomedical Materials Research Part B: Applied Biomaterials

      Volume: in press Issue: 8 Pages: 1730-1737

    • DOI

      10.1002/jbm.b.33522

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Application of clotrimazole via a novel controlled release device provides potent retinal protection2015

    • Author(s)
      Zhaleh Kashkouli Nezhad, Nobuhiro Nagai, Kotaro Yamamoto, Hirokazu Kaji, Matsuhiko Nishizawa, Hideyuki Saya, Toru Nakazawa, Toshiaki Abe
    • Journal Title

      J Mater Sci Mater Med

      Volume: 26 Issue: 9 Pages: 5561-5561

    • DOI

      10.1007/s10856-015-5561-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A polymeric device for controlled transscleral multi-drug delivery to the posterior segment of the eye2014

    • Author(s)
      Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Yumi Ishikawa, Matsuhiko Nishizawa, Noriko Osumi, Toru Nakazawa, Toshiaki Abe
    • Journal Title

      Acta Biomaterialia

      Volume: 10(2) Issue: 2 Pages: 680-6877

    • DOI

      10.1016/j.actbio.2013.11.004

    • NAID

      40020425298

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer2014

    • Author(s)
      Toshinori Fujie, Yoshihiro Mori, Shuntaro Ito, Matsuhiko Nishizawa, Hojae Bae, Nobuhiro Nagai, Hideyuki Onami, Toshiaki Abe, Ali Khademhosseini, Hirokazu Kaji
    • Journal Title

      Adv. Mater

      Volume: 26 Issue: 29 Pages: 1699-1705

    • DOI

      10.1002/adma.201301300

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Platform for Controlled Dual-Drug Delivery to the Retina : Protective Effects against Light-Induced Retinal Damage in Rats2014

    • Author(s)
      N Nagai, H Kaji, H Onami, Y Katsukura, Y Ishikawa, ZK Nezhad, K Sampei, S Iwata, S Ito, M Nishizawa, T Nakazawa, N Osumi, Y Mashima, T Abe
    • Journal Title

      Advanced Healthcare Materials

      Volume: in press Issue: 10 Pages: 680-687

    • DOI

      10.1002/adhm.201400114

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 高分子薄膜を用いたインジェクション可能な薬剤徐放デバイスの開発2016

    • Author(s)
      近藤太郎, Zhaleh Kashkouli Nezhad, 綱島俊一, 陳俐君, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
    • Organizer
      第28回バイオエンジニアリング講演会
    • Place of Presentation
      東京工業大学、東京
    • Year and Date
      2016-01-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 自己展開型薬剤徐放高分子デバイスの開発2015

    • Author(s)
      近藤太郎, Zhaleh Kashkouli Nezhad, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
    • Organizer
      化学とマイクロ・ナノシステム学会
    • Place of Presentation
      北九州国際会議場、福岡
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Polymeric thin films for cell and drug delivery2015

    • Author(s)
      Hirokazu Kaji
    • Organizer
      IEEE-NANOMED 2015
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2015-11-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高分子薄膜を用いた自己展開型薬剤徐放デバイスの開発2015

    • Author(s)
      近藤太郎, Zhaleh Kashkouli Nezhad, 綱嶋俊一, 陳 俐君, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] ミクロ細孔を有するタンパク質徐放デバイスに関する検討2015

    • Author(s)
      山田慎二, 永井展裕, 勝山 綾, 泉田泰子, 小柳恵理, 梶 弘和, 後藤昌史, 阿部俊明
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ、京都
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Injectable nanosheets as promising drug delivery systems for retinal disorders2015

    • Author(s)
      Zhaleh Kashkouli Nezhad, 近藤太郎, 梶 弘和, 永井展裕, 西澤松彦, 阿部俊明
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ、京都
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 眼局所持続性抗がん剤徐放デバイスの開発2015

    • Author(s)
      永井展裕, 勝山 綾, 泉田泰子, 小柳恵理, 山田慎二, 梶 弘和, 阿部俊明
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ、京都
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Injectable ultrathin polymeric films for subretinal cell delivery2015

    • Author(s)
      Hirokazu Kaji, Taro Kondo, Nobuhiro Nagai, Toshiaki Abe
    • Organizer
      2015 BMES Annual Meeting
    • Place of Presentation
      Tampa, Florida, USA
    • Year and Date
      2015-10-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Injectable polymeric nanosheets for subretinal cell delivery2015

    • Author(s)
      Hirokazu Kaji, Taro Kondo, Yoshihiro Mori, Nobuhiro Nagai, Toshiaki Abe
    • Organizer
      4th TERMIS World Congress
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高分子薄膜を用いた薬剤徐放デバイスの開発2015

    • Author(s)
      近藤太郎, Zhaleh Kashkouli Nezhad, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
    • Organizer
      第31回日本DDS学会学術集会
    • Place of Presentation
      京王プラザホテル、東京
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cell manipulation based on micro/nanotechnologies and biomedical application2015

    • Author(s)
      Hirokazu Kaji
    • Organizer
      7th International Symposium on Microchemistry and Microsystems (ISMM)
    • Place of Presentation
      Kyoto
    • Year and Date
      2015-06-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マイクロ・ナノ技術を用いた細胞操作と医工領域への展開2015

    • Author(s)
      梶 弘和
    • Organizer
      電気化学会第82回大会
    • Place of Presentation
      横浜、横浜国立大学
    • Year and Date
      2015-03-15 – 2015-03-17
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ラット眼球網膜下への細胞担持ナノシートデリバリー2014

    • Author(s)
      森 好弘, 藤枝俊宣, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
    • Organizer
      第36回日本バイオマテリアル学会大会
    • Place of Presentation
      東京、タワーホール船堀
    • Year and Date
      2014-11-17 – 2014-11-18
    • Related Report
      2014 Research-status Report
  • [Presentation] ナノシートを用いる眼内細胞送達システムの開発2014

    • Author(s)
      森 好弘, 藤枝俊宣, 永井展裕, 西澤松彦, 阿部俊明
    • Organizer
      第30回日本DDS学会学術集会
    • Place of Presentation
      東京、慶應義塾大学
    • Year and Date
      2014-07-30 – 2014-07-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Local delivery of an engineered epithelial monolayer by micropatterned polymeric Nanosheets2014

    • Author(s)
      Hirokazu Kaji, Toshinori Fujie, Nobuhiro Nagai, Toshiaki Abe
    • Organizer
      ARVO 2014 Annual Meeting
    • Place of Presentation
      Orland, Florida, USA
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Cell delivery system using micropatterned polymeric nanosheets2014

    • Author(s)
      Hirokazu Kaji, Toshinori Fujie, Yoshinori Mori, Nobuhiro Nagai, Ali Khademhosseini, Toshiaki Abe
    • Organizer
      2014 Annual Meeting of the Society For Biomaterials
    • Place of Presentation
      Denver, CO, USA
    • Year and Date
      2014-04-16 – 2014-04-19
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 薬剤徐放デバイス2015

    • Inventor(s)
      梶弘和,近藤太郎,ジャレカシュクリネジャド,永井展裕,阿部俊明
    • Industrial Property Rights Holder
      梶弘和,近藤太郎,ジャレカシュクリネジャド,永井展裕,阿部俊明
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-110747
    • Filing Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 形状制御されたナノシート及びその製造方法2015

    • Inventor(s)
      岩瀬英治,新保創太,武岡真司,藤枝俊宣,梶弘和,阿部俊明
    • Industrial Property Rights Holder
      岩瀬英治,新保創太,武岡真司,藤枝俊宣,梶弘和,阿部俊明
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-043990
    • Filing Date
      2015-03-05
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 細胞担持パターン化ナノ薄膜2014

    • Inventor(s)
      梶弘和,藤枝俊宣,森好弘,西澤松彦,阿部俊明,永井展裕
    • Industrial Property Rights Holder
      梶弘和,藤枝俊宣,森好弘,西澤松彦,阿部俊明,永井展裕
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-06-27
    • Related Report
      2014 Research-status Report
    • Overseas

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Published: 2014-04-04   Modified: 2017-05-10  

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