| Project/Area Number |
26560240
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
Jo Jun-ichiro 京都大学, 再生医科学研究所, 助教 (60511243)
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| Co-Investigator(Kenkyū-buntansha) |
TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | エクソソーム / ナノ粒子 |
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| Outline of Final Research Achievements |
Exosome is one of vesicles secreted from cells. Recently, it has been revealed that disease-derived exosomes are involved in the onset and malignant alteration of various diseases. It is no doubt that the technology-based artificial control of dynamics and biological function in disease-derived exosomes enables to suppress the onset and malignant alteration of diseases. The objective of this study was to develop a technology called “in vivo nano-surgery technology”, which can regulate the internal biological information of disease-derived exosome by making use of nanotechnology. To achieve the technology, in this study, a biodegradable nanocomplex was attempted to prepare by the modification of antibody with an affinity for the exosome and the encapsulation of a membrane-disrupting peptide and regulation factor.
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