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Preparation of cellular roll for regenerative artificial blood vessels using biodegradable shape-memory polymers

Research Project

Project/Area Number 26560248
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionKansai University

Principal Investigator

Ohya Yuichi  関西大学, 化学生命工学部, 教授 (10213886)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords形状記憶ポリマー / 人工血管 / 生分解性高分子 / 階層構造 / 再生医療 / 生分解性ポリマー
Outline of Final Research Achievements

In order to regenerate the living tissue, reconstruction of 3-dimensional hierarchical structures of the tissue must be important. In this study, we tried to prepare a biodegradable multi-layered cellular roll having 3-dimensional hierarchical structure consisting of different kind cells using biodegradable shape memory polymers as scaffolds for regenerative small diameter blood vessels. Then, we succeeded to prepare biodegradable polymer sheet which shows shape-recovery into roll shape. We succeeded immobilization of cell-recognition peptide on the surface of the polymer sheet.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (21 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (12 results) (of which Int'l Joint Research: 1 results) Book (6 results)

  • [Journal Article] Stereocomplex- and Homo-Crystallization of Blends from 2-Armed Poly(L-lactide) and Poly(D-lactide) with Identical and Opposite Chain Directional Architectures and of 2-Armed Stereo Diblock Poly(lactide)2016

    • Author(s)
      Hideto Tsuji, Kentaro Tamai, Toshiyuki Kimura, Akiyo Kubota, Akihiro Takahashi, Akinori Kuzuya, Yuichi Ohya
    • Journal Title

      Polymer

      Volume: 印刷中 Pages: 167-181

    • DOI

      10.1016/j.polymer.2016.04.049

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Automatic Recognition of DNA Pliers in Atomic Force Microscopy Images2015

    • Author(s)
      Han Y., Hara A., Kuzuya A., Watanabe R., Ohya Y., Konagaya A.
    • Journal Title

      New Generation Computing

      Volume: 33 Issue: 3 Pages: 253-270

    • DOI

      10.1007/s00354-015-0305-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Preparation of growth factor-loaded biodegradable matrices consisting of poly(depsipeptide-co-lactide) and cell growth on the matrices2014

    • Author(s)
      Yuichi Ohya, Jun Matori, Tatsuro Ouchi
    • Journal Title

      Reactive Functional Polymers

      Volume: 81 Pages: 33-39

    • DOI

      10.1016/j.reactfunctpolym.2014.04.003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] ポリマーの形状回復能を用いた血管再生用足場を目指した生分解性チューブ構造体の作成2015

    • Author(s)
      長畑聡記
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ(京都府)
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 血管再生用足場としての利用を意図した電界紡糸法による階層化チューブ構造体の作製2015

    • Author(s)
      西村和紀
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ(京都府)
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] ペプチド修飾脱細胞血管の開存と組織再生機構の解明2015

    • Author(s)
      飯田啓太
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ(京都府)
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Biodegradable Hierarchical Tubular Structures as Scaffolds for Regenerative Blood Vessels Prepared by Electrospinning2015

    • Author(s)
      Kazuki Nishimura
    • Organizer
      The 11th International Conference on Advanced Polymers via Macromolecular Engineering
    • Place of Presentation
      Pacifico Yokohama (Japan)
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] オリゴ乳酸-ペプチドヘテロ結合体によるポリ乳酸表面修飾2015

    • Author(s)
      飯田啓太
    • Organizer
      日本バイオマテリアル学会 第10回関西若手研究発表会
    • Place of Presentation
      関西大学(大阪府)
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 血管再生用分解性スキャフォールドを目指した階層化チューブ構造体の電界紡糸法による作製2015

    • Author(s)
      西村和紀
    • Organizer
      日本バイオマテリアル学会 第10回関西若手研究発表会
    • Place of Presentation
      関西大学(大阪府)
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 小口径人工血管用スキャフォールドを目指した形状記憶ポリマーを用いた生分解性チューブ構造体の作成2015

    • Author(s)
      長畑聡記
    • Organizer
      日本バイオマテリアル学会 第10回関西若手研究発表会
    • Place of Presentation
      関西大学(大阪府)
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] オリゴ乳酸-ペプチドヘテロ融合体によるポリ乳酸表面修飾の安定性評価2015

    • Author(s)
      飯田啓太
    • Organizer
      第61回高分子研究発表会(神戸)
    • Place of Presentation
      兵庫県民会館(兵庫県)
    • Year and Date
      2015-07-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Fabrication of Hierarchical Biodegradable Tubular Structures as Scaffolds for Regenerative Blood Vessels by Electrospinning2015

    • Author(s)
      西村和紀
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Preparation of Biodegradable Multi-layered Tubular Structures as Scaffolds for Regeneration of Blood Vessels2014

    • Author(s)
      Toshiki Nagahata
    • Organizer
      9th International Symposium in Science and Technology at Cheng Shiu University 2014
    • Place of Presentation
      Cheng Shiu University (Kaohsiung, Taiwan)
    • Year and Date
      2014-08-18 – 2014-08-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 再生人工血管を目指した生分解性スキャフォールドを用いた多層細胞ロールの調製2014

    • Author(s)
      長畑聡記
    • Organizer
      日本バイオマテリアル学会 第9回関西若手研究発表会
    • Place of Presentation
      京都大学桂キャンパス(京都府)
    • Year and Date
      2014-08-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 再生人工血管用スキャフォールドを目指した生分解性形状記憶ポリマーによる多層チューブ構造の作成2014

    • Author(s)
      髙橋明裕
    • Organizer
      第63回高分子学会年次大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2014-05-28 – 2014-05-30
    • Related Report
      2014 Research-status Report
  • [Book] バイオマテリアル その基礎と先端研究への展開2016

    • Author(s)
      大矢裕一
    • Total Pages
      368
    • Publisher
      東京化学同人
    • Related Report
      2015 Annual Research Report
  • [Book] Biomaterials Nanoarchitectonics2016

    • Author(s)
      Yuichi Ohya
    • Total Pages
      362
    • Publisher
      Elsevier
    • Related Report
      2015 Annual Research Report
  • [Book] CSJカレントレビュー24『化学で医療・診断・創薬の革新を目指す』2016

    • Author(s)
      大矢裕一
    • Publisher
      化学同人
    • Related Report
      2015 Annual Research Report
  • [Book] Encyclopedia of Polymeric Nanomaterials2015

    • Author(s)
      Yuichi Ohya
    • Total Pages
      2617
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] 進化する医療用バイオベースマテリアル2015

    • Author(s)
      大矢裕一
    • Total Pages
      272
    • Publisher
      シーエムシー出版
    • Related Report
      2014 Research-status Report
  • [Book] 生体適合性制御と要求特性掌握から実践する高分子バイオマテリアルの設計・開発戦略~モノマー(いち)からデザインするバイオインターフェースと上市までの道筋~2014

    • Author(s)
      大矢裕一
    • Total Pages
      432
    • Publisher
      サイエンス&テクノロジー
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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