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Beating cardiomyocyte induction from iPS cells on acellular cardiac tissues with native biological niche

Research Project

Project/Area Number 26560251
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Yamaoka Tetsuji  国立研究開発法人国立循環器病研究センター, 研究所, 部長 (50243126)

Co-Investigator(Kenkyū-buntansha) HIRATA Mitsuhi  国立研究開発法人国立循環器病研究センター, 研究所, 非常勤研究員 (80568452)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords細胞 / 組織工学材料 / 細胞・組織工学材料 / 脱細胞組織 / 幹細胞ニッチ / 分化誘導 / 心筋細胞 / 肝細胞 / 神経細胞
Outline of Final Research Achievements

Regenerative medicine to transplant variour autologous stem cells such as mesenchyma system stem cells is attracting great attention for treating myocardial infarction or other deceases. However, its effect is known to be the paracline effect and is not satisfactory. Therefore, as a more effective stragegy, transplantation of the functional cells such as beating cardiomyoblasts induced from the induced pluripotent stem cells have been proposed. In this project, we confirmed the usefulness of acellular tissue derived from pocine heart, liver, and brain as the cell culture matriced in iPC differentiation induction.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2014

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 2 results) Presentation (10 results) Book (1 results)

  • [Journal Article] Mobility of the Arg-Gly-Asp ligand on the outermost surface of biomaterials suppresses integrin-mediated mechanotransduction and subsequent cell functions2015

    • Author(s)
      S. Kakinoki, J-H. Seo, Y. Inoue, K. Ishihara, N. Yui, *T. Yamaoka
    • Journal Title

      Acta Biomaterialia

      Volume: 13 Pages: 42-51

    • DOI

      10.1016/j.actbio.2014.11.020

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Directing stem cell differentiation by changing the molecular mobility of supramolecular surfaces2015

    • Author(s)
      J.-H. Seo, S. Kakinoki, T. Yamaoka, N. Yui
    • Journal Title

      Advanced Healthcare Materials

      Volume: 4 Issue: 2 Pages: 215-215

    • DOI

      10.1002/adhm.201400173

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Single-step immobilization of cell adhesive peptides on a variety of biomaterial substrates via tyrosine oxidation with copper catalyst and hydrogen peroxide2015

    • Author(s)
      S. Kakinoki and T.Yamaoka
    • Journal Title

      Bioconjugate Chemistry

      Volume: 26 Issue: 4 Pages: 639-644

    • DOI

      10.1021/acs.bioconjchem.5b00032

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quick nuclear transportation of siRNA and in vivo hepatic ApoB gene silencing with galactose-bearing polymeric carrier2014

    • Author(s)
      Y. Tachibana, M. C. Munisso, W. Kamata, M. Kitagwa, M. H. Shiba, and T. Yamaoka
    • Journal Title

      Journal of Biotechnology

      Volume: 175 Pages: 15-21

    • DOI

      10.1016/j.jbiotec.2014.01.029

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reliable assessment and quantification of the fluorescence-labeled antisense oligonucleotides in vivo2014

    • Author(s)
      M. C. Munisso and T. Yamaoka
    • Journal Title

      BioMed Res. Int.

      Volume: 2014 Pages: 196837-196837

    • DOI

      10.1155/2014/196837

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phospholipid polymer–based antibody immobilization for cell-rolling surfaces in stem cell purification system2014

    • Author(s)
      A. Mahara, H. Chen, K. Ishihara, and T. Yamaoka
    • Journal Title

      Journal of Biomaterials Science, Polymer Edition

      Volume: 25 Issue: 14-15 Pages: 1590-1601

    • DOI

      10.1080/09205063.2014.936926

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gene chip/PCR-array analysis of tissue response to 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer surfaces in a mouse subcutaneous transplantation system2014

    • Author(s)
      Sachiro Kakinoki, Yusuke Sakai, Taro Takemura, Nobutaka Hanagata, Toshia Fujisato, Kazuhiko Ishihara, Tetsuji Yamaoka
    • Journal Title

      Journal of Biomaterials Science, Polymer Edition

      Volume: 25 Issue: 14-15 Pages: 1658-1672

    • DOI

      10.1080/09205063.2014.939917

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] シルクフィブロイン上で培養したiPS細胞の未分化維持2016

    • Author(s)
      佐々木瑞樹、平田みつひ、山岡哲二、玉田靖
    • Organizer
      つくば医工連携フォーラム2016
    • Place of Presentation
      産総研
    • Year and Date
      2016-01-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] エラスチン様タンパクゲル中でのラット間葉系幹細胞の心筋分化培養2015

    • Author(s)
      徳重恭之, 神戸裕介, 馬原淳, 岩﨑泰彦, 山岡哲二
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 間葉系幹細胞の心筋細胞分化を誘導するエラスチン様リコンビナントタンパクゲル2015

    • Author(s)
      徳重恭之, 神戸裕介, 馬原淳, 岩﨑泰彦, 山岡哲二
    • Organizer
      日本バイオマテリアル学会 第10回関西若手発表会
    • Place of Presentation
      関西大学
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 未分化iPS細胞の分離のための抗体固定化ポリマー被覆マイクロ流路の開発2015

    • Author(s)
      大高晋之, 北川和宜, 平田みつひ, 深澤今日子, 中沖隆彦, 石原一彦, 馬原淳, 山岡哲二
    • Organizer
      第44回医用高分子シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-07-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Myocardial differentiation of rat mesenchymal stem cells in elastin-like recombinant protein gels2015

    • Author(s)
      Takayuki Tokushige, Yusuke Kambe, Atsushi Mahara, Yasuhiko Iwasaki, Tetsuji Yamaoka
    • Organizer
      第64回高分子年次大会
    • Place of Presentation
      札幌
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 表面化学的特性の異なる多孔質体への軟組織浸潤誘導2015

    • Author(s)
      安田裕貴
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      日本大学理工学部船橋キャンパス
    • Year and Date
      2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] bFGFの非共有結合的固定化による多孔質スキャホールドへの組織浸潤誘導2015

    • Author(s)
      柿木佐知朗
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] MPCポリマー修飾表面が誘起する炎症関連遺伝子発現の変動2014

    • Author(s)
      柿木佐知朗
    • Organizer
      第36回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2014-11-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 動的ポリロタキサン表面における間葉系幹細胞の分化特性評価2014

    • Author(s)
      徐 知勲
    • Organizer
      第36回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2014-11-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 分子運動性の異なるポリロタキサン表面上における間葉系幹細胞の分化特性2014

    • Author(s)
      徐 知勲
    • Organizer
      第43回医用高分子シンポジウム
    • Place of Presentation
      産業技術総合研究所臨海副都心センター
    • Year and Date
      2014-07-29
    • Related Report
      2014 Research-status Report
  • [Book] 高機能性繊維の最前線~医療,介護,ヘルスケアへの応用2014

    • Author(s)
      橋本朋子、玉田 靖、山岡哲二
    • Total Pages
      10
    • Publisher
      シーエムシー出版
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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