| Project/Area Number |
26560252
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical systems
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| Research Institution | Tohoku University |
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Principal Investigator |
Terakawa Atsuki 東北大学, 工学(系)研究科(研究院), 教授 (10250854)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUYAMA SHIGEO 東北大学, 大学院工学研究科, 准教授 (70219525)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 粒子線治療 / PIXE分析 / ドラッグデリバリー |
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| Outline of Final Research Achievements |
We performed therapeutic experiments using tumor-bearing mice to develop proton therapy combined with chemotherapy using cisplatin incorporated polymeric micelles (CDDP). The experimental results showed that the combined-treatment increased the tumor growth delay additively compared to proton therapy alone or chemotherapy with CDDP alone. The concentrations of CDDP in the samples of the tumor and normal tissues were evaluated using particle-induced X-ray emission (PIXE) analysis. We found that the concentration of CDDP in the tumor tissue was much higher than that in the normal tissue. Judging from the results of the therapeutic experiments and the PIXE analysis, it is suggested that CDDP was selectively delivered to the tumor tissue by the tumor blood flow, and that proton therapy combined with chemotherapy with CDDP induced the significant tumor growth delay with lower side-effects.
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