Development and optimization of ion-beam therapy combined with drug-delivery system

• Project/Area Number: 26560252
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical systems
• Research Institution: Tohoku University
• Principal Investigator: Terakawa Atsuki 東北大学, 工学(系)研究科(研究院), 教授 (10250854)
• Co-Investigator(Kenkyū-buntansha): MATSUYAMA SHIGEO 東北大学, 大学院工学研究科, 准教授 (70219525)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 粒子線治療 / PIXE分析 / ドラッグデリバリー

Outline of Final Research Achievements

We performed therapeutic experiments using tumor-bearing mice to develop proton therapy combined with chemotherapy using cisplatin incorporated polymeric micelles (CDDP). The experimental results showed that the combined-treatment increased the tumor growth delay additively compared to proton therapy alone or chemotherapy with CDDP alone. The concentrations of CDDP in the samples of the tumor and normal tissues were evaluated using particle-induced X-ray emission (PIXE) analysis. We found that the concentration of CDDP in the tumor tissue was much higher than that in the normal tissue. Judging from the results of the therapeutic experiments and the PIXE analysis, it is suggested that CDDP was selectively delivered to the tumor tissue by the tumor blood flow, and that proton therapy combined with chemotherapy with CDDP induced the significant tumor growth delay with lower side-effects.

Research Products

• [Journal Article] Concentration of cisplatin-incorporated polymeric micelles in a murine solid tumor evaluated using PIXE analysis (2015)
  • Author(s): A. Terakawa, K. Ishii, S. Matsuyama et al.
  • Journal Title: International Journal of PIXE Volume: 24 Pages: 41-47
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 68.A micro-pattern gaseous detector for beam monitoring in ion-therapy (2015)
  • Author(s): A. Terakawa, K. Ishii, S. Matsuyama et al.
  • Journal Title: Nuclear Instruments and Methods in Physics Research B Volume: 365 Pages: 606-610
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] CONCENTRATION OF CISPLATIN-INCORPORATED POLYMERIC MICELLES IN MURICE SOLID TUMOR EVALUATED USING PIXE ANALYSIS (2015)
  • Author(s): A. Terakawa, K. Ishii, S. Matsuyama et al.
  • Journal Title: International Journal of PIXE Volume: 24
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] STUDIES ON RADIOACTIVE CESIUM AND ALKALI ELEMENTS IN LENTINULA EDODES (SHIITAKE) BASED ON PIXE ANALYSIS (2015)
  • Author(s): A. Terakawa, K. Ishii, S. Matsuyama et al.
  • Journal Title: International Journal of PIXE Volume: 23 Pages: 147-151
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] A micro-pattern gaseous detector for beam monitoring in ion-therapy (2015)
  • Author(s): TERAKAWA Atsuki, ISHII Keizo, MATSUYAMA Shigeo et al.
  • Organizer: Swift heavy ion in matter 2015
  • Place of Presentation: ダルムシュタット、ドイツ
  • Year and Date: 2015-05-18
  • Int'l Joint Research
• [Presentation] マイクロパータンガス検出器の粒子線治療モニターへの応用 (2015)
  • Author(s): 佐藤剛、寺川貴樹、他
  • Organizer: 日本原子力学会
  • Place of Presentation: 茨城大学、茨城県日立市
  • Year and Date: 2015-03-20 – 2015-03-22
• [Presentation] Three-dimensional image acquisition method by using PIXE analysis (2014)
  • Author(s): T. Matsuyama, A. Terakawa et al.
  • Organizer: 8th International Symposium on BioPIXE (BioPIXE8)
  • Place of Presentation: スロベニア、ブレッド市
  • Year and Date: 2014-09-14 – 2014-09-19
• [Presentation] 粒子線治療 (2014)
  • Author(s): 寺川貴樹
  • Organizer: 日本機械学会
  • Place of Presentation: 東京電機大学、東京都足立区
  • Year and Date: 2014-09-07 – 2014-09-10
  • Invited