| Project/Area Number |
26560256
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical systems
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| Research Institution | Fujita Health University (2015)
Nagoya Institute of Technology (2014) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUMOTO Takeo 名古屋工業大学, 工学(系)研究科(研究院), 教授 (30209639)
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| Research Collaborator |
MASUDA Hiroshi (株)ユネクス, 社長
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 動脈硬化 / スティフネス / 上腕動脈 / FMD |
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| Outline of Final Research Achievements |
We noticed that the stiffness of an aorta increased in the early stage of atherosclerosis in high-pressure ranges. In this study, we have thus established a new method in which the transmural pressure (Tp) of the brachial artery is manipulated to determine the pressure-strain elastic modulus (Ep) of the artery in a high-pressure range.
A rigid airtight chamber is attached to the upper arm to manipulate the Tp of the brachial artery by changing the pressure in the chamber. The Ep of the artery is obtained by measuring the diameter change immediately after the stepwise application of negative pressure inside the chamber. Artery stiffness was significantly higher in a high-pressure range than in the physiological pressure range in subjects elder group but not in subjects younger group. These results indicate that the arteries become stiffer in a high-pressure region with aging. Stiffness in high-pressure regions might be a good index to detect the early stage of atherosclerosis.
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