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Development of freely deformable neutron shield for boron neutron capture therapy

Research Project

Project/Area Number 26560258
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Medical systems
Research InstitutionKyoto University

Principal Investigator

Tanaka Hiroki  京都大学, 原子炉実験所, 准教授 (70391274)

Co-Investigator(Kenkyū-buntansha) 櫻井 良憲  京都大学, 原子炉実験所, 准教授 (20273534)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords中性子捕捉療法 / 遮蔽材 / 加速器中性子源
Outline of Final Research Achievements

The purpose of this study is to develop a shielding material that can be applied to a mixture of neutrons and gamma rays with different energies in boron neutron capture therapy and to develop a new neutron measurement method. We found that freely deformable shielding material filled with LiF loaded polyethylene particles in suction bag was applied to humanoid phantom. This shielding was able to decrease thermal neutron and fast neutron dose by 70% and 50%, respectively. A combination of activation foil and imaging plate was proposed as a new neutron measurement method. It was confirmed that the result of this method for thermal neutrons was good agreement with the activation method. Furthermore, irradiation test was carried out using aluminum activation foil for fast neutrons, and the neutron distribution was successfully acquired.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (27 results)

All 2018 2017 2016 2015 2014

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (22 results) (of which Int'l Joint Research: 5 results,  Invited: 7 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] NOTE:Development of real-time epithermal neutron detector for boron neutron capture therapy.2017

    • Author(s)
      Tanaka H, Sakurai Y, Takata T, Watanabe T, Kawabata S, Suzuki M, Masunaga S, Taki K, Akabori K, Watanabe K, Ono K.
    • Journal Title

      Review of Scientific Instruments

      Volume: 88 Issue: 5 Pages: 56101-56101

    • DOI

      10.1063/1.4982036

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improvement of depth dose distribution using multiple-field irradiation in boron neutron capture therapy2015

    • Author(s)
      N. Fujimoto, H. Tanaka, Y. Sakurai, T. Takata, N. Kondo, M. Narabayashi, Y. Nakagawa, T. Watanabe, Y. Kinashi, S. Masunaga, A. Maruhashi, K. Ono, M. Suzuki,
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 106 Pages: 134-138

    • DOI

      10.1016/j.apradiso.2015.07.041

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] サイクロトロン加速器BNCT照射システム(C-BENS)の開発と今後の展望2015

    • Author(s)
      田中浩基
    • Journal Title

      RADIOISOTOPES

      Volume: 64 Pages: 29-36

    • NAID

      130004803059

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] BNCTのためのLaBr3(Ce)シンチレーターとMPPCアレイを用いた 即発γ線イメージング検出器の開発2018

    • Author(s)
      岡崎 啓太, 赤堀 清崇, 高田 卓志, 櫻井 良憲, 田 中 浩基
    • Organizer
      第65回応用物理学会春季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 原子炉実験所における加速器BNCT装置の概要2017

    • Author(s)
      田中浩基
    • Organizer
      京都大学原子炉実験所平成29年度専門研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] An overview of accelerator-based neutron source for BNCT2017

    • Author(s)
      Hiroki Tanaka
    • Organizer
      Current Clinical Status of Boron Neutron Capture Therapy and Paths to the Future
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Accelerator based neutron source for BNCT2017

    • Author(s)
      Hiroki Tanaka
    • Organizer
      International Conference on Neutron Optics2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] BNCTによる全身被曝を考える物理工学の観点から2017

    • Author(s)
      田中浩基
    • Organizer
      第14回日本中性子捕捉療法学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Boron neutron capture therapy combined with X-ray radiotheapy2017

    • Author(s)
      Hiroki Tanaka, Yoshinori Sakurai, Tatsuya Ageishi, Tsubasa Watanabe, Minoru Suzuki, Shin-ichiro Masunaga, Akira Maruhashi, Koji Ono,Shinji Kawabata, Kazuhiko Akita, Shin-ichi Miyatake
    • Organizer
      日本放射線腫瘍学会第30回学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of real-time neutron detector and prompt gamma-ray imaging monitor for BNCT2017

    • Author(s)
      Hiroki Tanaka , Yoshinori Sakurai, Takushi Takata, Tsubasa Watanabe, Kiyotaka Akabori,Minoru Suzuki, Shin-ichiro Masunaga, Akira Maruhashi, Koji Ono
    • Organizer
      9th Young Researchers' BNCT Meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] Study on dose reduction of normal tissue using freely deformable neutron shield for boron neutron capture therapy2017

    • Author(s)
      Hiroki Tanaka, Takushi Takata, Yuki Tamari, Yoshinori Sakurai, Tsubasa Watanabe, Minoru Suzuki, Shin-ichiro Masunaga, Akira Maruhashi, Koji Ono
    • Organizer
      8th Japan-Korea Joint Meeting on Medical Physics
    • Related Report
      2017 Annual Research Report
  • [Presentation] A study on improvement method of dose distribution using bolus in BNCT for head and neck tumors2016

    • Author(s)
      Y.Sakurai,,H. Tanaka,T.Takata,N.Kondo,T.Watanabe,Y.Kinashi,S.Masunaga,M.Suzuki,K.Ono,A.Maruhashi
    • Organizer
      日本放射線腫瘍学会第29回学術大会
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Development of remote-changeable Bonner-sphere spectrometer for QA/QC in BNCT2016

    • Author(s)
      Y. Sakurai, H. Ueda, R. Uchida, T. Takata, H. Tanaka
    • Organizer
      the 17th International Congress on Neutron Capture Therapy
    • Place of Presentation
      Missiuri,USA
    • Year and Date
      2016-10-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] マルチリーフコリメータを用いた中性子捕捉療法の3次元線量計算モデル2016

    • Author(s)
      武川哲也、山口喬、青木康、密本俊典、矢島暁、密本俊典、田中浩基、丸橋晃
    • Organizer
      第13回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2016-08-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 加速器中性子源によるBNCTの現状2016

    • Author(s)
      田中浩基、櫻井良憲、鈴木実、増永慎一郎、丸橋晃、小野公二
    • Organizer
      第18回 癌治療増感研究シンポジウム
    • Place of Presentation
      奈良県文化会館(奈良県奈良市)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Present status of BNCT System using 30 MeV Cyclotron2016

    • Author(s)
      T. Mitsumoto, S. Yajima, H. Tanaka, A. Maruhashi, M. Suzuki, K. Ono, T. Kato, K. Igawa, K. Hirose, K. Seto and Y. Takai
    • Organizer
      the 17th International Congress on Neutron Capture Therapy
    • Place of Presentation
      Missiuri,USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 最近のBNCTの物理・技術的動向について2016

    • Author(s)
      田中浩基
    • Organizer
      第5回JBMP放射線治療品質管理・医学物理講習会
    • Place of Presentation
      首都大学東京 荒川キャンパス(東京都荒川区)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 加速器BNCTにおける医学物理の基礎知識2015

    • Author(s)
      田中浩基、櫻井良憲、鈴木実、増永慎一郎、丸橋晃、小野公二
    • Organizer
      保物セミナー2015
    • Place of Presentation
      大阪科学技術センター(大阪府大阪市)
    • Year and Date
      2015-12-18
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Study on the extended collimator for Cyclotron-Based Epithermal Neutron Source (C-BENS)2015

    • Author(s)
      H. Tanaka, Y. Sakurai, T. Takata, N. Fujimoto, M. Suzuki , S. Masunaga , T. Mitsumoto, A. Maruhashi, K. Ono
    • Organizer
      8th Young Researchers BNCT Meeting
    • Place of Presentation
      Pavia, Italia
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] BNCTにおけるQA/QCの標準化について2015

    • Author(s)
      田中 浩基、櫻井 良憲、熊田 博明
    • Organizer
      第12回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      神戸学院大学(兵庫県神戸市)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
  • [Presentation] ホウ素中性子捕捉療法のための リアルタイム熱外中性子束モニターの開発2015

    • Author(s)
      田中浩基, 櫻井良憲, 鈴木実, 増永慎一郎,  渡辺賢一, 滝和也, 丸橋晃, 小野公二
    • Organizer
      日本原子力学会2015年春の年会
    • Place of Presentation
      茨城大学(茨城県日立市)
    • Year and Date
      2015-03-20 – 2015-03-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of real time neutron monitors for BNCT2014

    • Author(s)
      H. Tanaka, Y. Sakurai, M. Suzuki, S. Masunaga, Y. Kinashi, K. Taki, T. Fujii, N. Fujimoto, T.Takata, T. Watanabe, Y. Nakagawa, M. Narabayashi, N. Kondo, A. Maruhashi, K. Ono
    • Organizer
      2nd International workshop on BNCT
    • Place of Presentation
      京都大学(京都府京都市)
    • Year and Date
      2014-12-09 – 2014-12-10
    • Related Report
      2014 Research-status Report
  • [Presentation] BNCTで行われている 放射線検出器に関する研究2014

    • Author(s)
      田中浩基
    • Organizer
      放射線検出器の研究シーズと医療現場ニーズに関するシンポジウム
    • Place of Presentation
      首都大学東京(東京都荒川区)
    • Year and Date
      2014-11-29
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] リアルタイム中性子検出器の開発2014

    • Author(s)
      田中浩基、櫻井良憲、鈴木実、増永慎一郎、 木梨友子、近藤夏子、楢林正流、仲川洋介、 藤本望、高田卓志、渡邉翼、代谷誠治、高橋千太郎、 滝和也、酒井文雄、青木康、丸橋晃、小野公二
    • Organizer
      平成26年度京大炉専門研究会
    • Place of Presentation
      京都大学原子炉実験所(大阪府泉南郡熊取町)
    • Year and Date
      2014-09-26 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] ホウ素中性子捕捉療法の現状について2014

    • Author(s)
      田中浩基
    • Organizer
      放射線科学とその応用第186委員会 第12回研究会
    • Place of Presentation
      名古屋大学(愛知県名古屋市)
    • Year and Date
      2014-07-30
    • Related Report
      2014 Research-status Report
    • Invited
  • [Patent(Industrial Property Rights)] 中性子捕捉療法システム2016

    • Inventor(s)
      武川哲也、滝和也、田中浩基
    • Industrial Property Rights Holder
      武川哲也、滝和也、田中浩基
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-10-27
    • Related Report
      2016 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] 中性子捕捉療法シミュレーションシステム及び中性子捕捉療法シミュレーション方法2015

    • Inventor(s)
      武川哲也、田中浩基
    • Industrial Property Rights Holder
      武川哲也、田中浩基
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-210689
    • Filing Date
      2015-10-27
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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