Computer-aided detection of metastatic diseases in lympha node, liver, and lung from colorectal cancer

• Project/Area Number: 26560260
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical systems
• Research Institution: The University of Tokushima
• Principal Investigator: Kawata Yoshiki 徳島大学, ソシオテクノサイエンス研究部, 准教授 (70274264)
• Co-Investigator(Kenkyū-buntansha): NIKI Noboru 徳島大学, 大学院ソシオテクノサイエンス研究部, 教授 (80116847) ; SHIMADA Mitsuo 徳島大学, 大学院医歯薬学研究部, 教授 (10216070) ; IINUMA Gen 国立研究開発法人国立がん研究センター, 中央病院, 医長 (60222824)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 大腸がん転移巣 / 造影CT画像診断支援システム / 胸腹部造影CT画像データベース / 血管ネットワーク構造解析法 / 造影CT 画像診断支援システム / 胸腹部造影CT 画像データベース

Outline of Final Research Achievements

The purpose of this study was to develop and evaluate the effectiveness of a computerized approach that detects metastatic diseases in lympha node, liver, and lung from colorectal cancer. For that, we performed the following four subprojects; (1) establishing a database of torso CT images with contrast material and diagnosis reports, (2) developing a structure analysis method of vessel network in torso organs, (3) developing a detection method of metastatic diseases in lymapa node, liver, and lung through vessel network analysis, and (4) developing computer-aided detection system of metastatic diseases. Preliminary experimental results using the established database suggested that the quantitative analysis of vessel network structures in torso organs can characterize indications of metastatic diseases which are spread from colorectal cancer.

Research Products

• [Journal Article] 計算解剖モデルに基づく診断支援 (2014)
  • Author(s): 仁木登，河田佳樹，鈴木秀宣，松廣幹雄
  • Journal Title: INNERVISION Volume: 29 Pages: 19-21
  • NAID: 130000886607
• [Presentation] Automatic bone of torso segmentation using contrast enhanced CT (2016)
  • Author(s): A.S.Maklad, M.Matsuhiro, H.Suzuki, Y.Kawata, N.Niki, T.Utsunomiya, M.Shimada
  • Organizer: 1st Asia Oceania Workshop of Pulmonary Functional Imaging combined with 8th Japanese Society of Pulmonary Functional Imaging
  • Place of Presentation: Awaji Yumebutai International Conference Center (Awaji City, Hyogo, Japan)
  • Year and Date: 2016-01-29
  • Int'l Joint Research
• [Presentation] 多時相造影CTにおける転移性リンパ節の解析 (2016)
  • Author(s): 井村涼太，掛田貴章，尾澤公亮，鈴木秀宣，河田佳樹，仁木登，島田光生，飯沼元
  • Organizer: 電子情報通信学会技術研究報告医用画像
  • Place of Presentation: 那覇市ぶんかテンブス館（沖縄県那覇市）
  • Year and Date: 2016-01-19
• [Presentation] 造影CT画像(動脈相・門脈相・平衡相)を用いた腹部血管画像解析 (2016)
  • Author(s): 掛田貴章，井村涼太，尾澤公亮，鈴木秀宣，河田佳樹，仁木登，島田光生，飯沼元
  • Organizer: 電子情報通信学会技術研究報告医用画像
  • Place of Presentation: 那覇市ぶんかテンブス館（沖縄県那覇市）
  • Year and Date: 2016-01-19
• [Presentation] 腹部造影CT画像における血管抽出と分類 (2015)
  • Author(s): 尾澤公亮，平島孝樹，鈴木秀宣，河田佳樹，仁木登，島田光生，飯沼元
  • Organizer: 日本医用画像工学会大会
  • Place of Presentation: 金沢歌劇座（石川県金沢市）
  • Year and Date: 2015-07-30
• [Presentation] 造影CT画像（動脈相・門脈相・平衡相）を用いた腹部血管画像解析 (2015)
  • Author(s): 掛田貴章，井村涼太，尾澤公亮，鈴木秀宣，河田佳樹，仁木登，島田光生，飯沼元
  • Organizer: 日本医用画像工学会大会
  • Place of Presentation: 金沢歌劇座（石川県金沢市）
  • Year and Date: 2015-07-30
• [Presentation] 胸腹部CT検診コンピュータ支援診断 (2015)
  • Author(s): 仁木登
  • Organizer: 第10回消化管CT技術研究会
  • Place of Presentation: 新宿明治安田生命ホール（東京都新宿区）
  • Year and Date: 2015-05-23
• [Presentation] Automatic blood vessel-based liver segmentation through the portal phase abdominal CT dataset (2015)
  • Author(s): Ahmed S.Maklad, M.Matsuhiro, H.Suzuki, Y.Kawata, N.Niki, M.Satake, N.Moriyama, T.Utsunomiya, M.Shimada:
  • Organizer: 電子情報通信学会技術研究報告医用画像
  • Place of Presentation: 三重大学（三重県津市）
  • Year and Date: 2015-05-14
• [Presentation] Nonlinear dimensionality reduction of CT histogram based feature space for predicting recurrence-free survival in non-small-cell lung cancer (2015)
  • Author(s): Y.Kawata, N.Niki, H.Ohmatsu, K.Aokage, M.Kusumoto, T.Tsuchida, K.Eguchi, M.Kaneko
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Renaissance Orlando (Orlando, Florida, United States)
  • Year and Date: 2015-02-21 – 2015-02-26
• [Presentation] Quantitative assessment of smoking-induced emphysema progression in longitudinal CT screening for lung cancer (2015)
  • Author(s): H.Suzuki, R.Mizuguchi, M.Matsuhiro, Y.Kawata, N.Niki, Y.Nakano, H.Ohmatsu, M.Kusumoto, T.Tsuchida, K.Eguchi, M.Kaneko, N.Moriyama
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Renaissance Orlando (Orlando, Florida, United States)
  • Year and Date: 2015-02-21 – 2015-02-26
• [Presentation] Peripleural lung disease detection based on multi-slice CT images (2015)
  • Author(s): M.Matsuhiro, H.Suzuki, Y.Kawata, N.Niki, Y.Nakano, H.Ohmatsu, M.Kusumoto, T.Tsuchida, K.Eguchi, M.Kaneko
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Renaissance Orlando (Orlando, Florida, United States)
  • Year and Date: 2015-02-21 – 2015-02-26
• [Presentation] Microstructure analysis of the pulmonary acinus using a synchrotron radiation CT (2015)
  • Author(s): Y.Tokumoto, K.Minami, Y.Kawata, N.Niki, K.Umetani, Y.Nakano, H.Sakai, H.Ohmatsu, H.Itoh
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Renaissance Orlando (Orlando, Florida, United States)
  • Year and Date: 2015-02-21 – 2015-02-26
• [Presentation] Recurrence-free survival prediction of non-small cell lung cancer based on a nonparametric Bayesian analysis of CT histograms (2014)
  • Author(s): Y.Kawata, N.Niki, H.Ohmatsu, K.Aokage, M.Kusumoto, T.Tsuchida, M.Satake, K.Eguchi, M.Kaneko, N.Moriyama
  • Organizer: CARS International Journal of Computer Assisted Radiology and Surgery
  • Place of Presentation: Fukuoka International Convention Center （福岡県福岡市）
  • Year and Date: 2014-06-25 – 2014-06-28
• [Presentation] Automatic extraction of abdominal blood vessel through the portal phase of a CT dataset (2014)
  • Author(s): A.Maklad, M.Matsuhiro, H.Suzuki, Y.Kawata, N.Niki, M.Satake, N.Moriyama, T.Utsunomiya, M.Shimada
  • Organizer: CARS International Journal of Computer Assisted Radiology and Surgery
  • Place of Presentation: Fukuoka International Convention Center （福岡県福岡市）
  • Year and Date: 2014-06-25 – 2014-06-28
• [Presentation] CADe and CADx for lung cancer CT images (2014)
  • Author(s): N.Niki
  • Organizer: CARS International Journal of Computer Assisted Radiology and Surgery
  • Place of Presentation: Fukuoka International Convention Center （福岡県福岡市）
  • Year and Date: 2014-06-25 – 2014-06-28
  • Invited