Development of theranostics for cancer with tumor targeted bubbles and ultrasound
Project/Area Number |
26560264
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Medical systems
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Research Institution | Teikyo University |
Principal Investigator |
Suzuki Ryo 帝京大学, 薬学部, 准教授 (90384784)
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Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 超音波 / がん / 診断 / 治療 / 超音波診断 / 超音波治療 / 免疫療法 |
Outline of Final Research Achievements |
In this study, we succeeded to develop novel bubbles with long half-life as ultrasound imaging agent. In addition, we modified the targeting peptide (cyclic RGD) on the bubbles. These bubbles could effectively bind to human umblical endothelial cells (HUVEC) as a model of neovascular endothelial cells in tumor tissue. From these results, it is expected that the developed bubbles would be applied for ultrasound imaging agents and therapeutic agents for cancer.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Tumor growth suppression by the combination of nanobubbles and ultrasound2016
Author(s)
Suzuki R, Oda Y, Omata D, Nishiie N, Koshima R, Shiono Y, Sawaguchi Y, Unga J,Naoi T, Negishi Y, Kawakami S, Hashida M, Maruyama K.
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Journal Title
Cancer Sci.
Volume: 107
Issue: 3
Pages: 217-113
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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