Development of theranostics for cancer with tumor targeted bubbles and ultrasound

• Project/Area Number: 26560264
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical systems
• Research Institution: Teikyo University
• Principal Investigator: Suzuki Ryo 帝京大学, 薬学部, 准教授 (90384784)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 超音波 / がん / 診断 / 治療 / 超音波診断 / 超音波治療 / 免疫療法

Outline of Final Research Achievements

In this study, we succeeded to develop novel bubbles with long half-life as ultrasound imaging agent. In addition, we modified the targeting peptide (cyclic RGD) on the bubbles. These bubbles could effectively bind to human umblical endothelial cells (HUVEC) as a model of neovascular endothelial cells in tumor tissue. From these results, it is expected that the developed bubbles would be applied for ultrasound imaging agents and therapeutic agents for cancer.

Research Products

• [Journal Article] Tumor growth suppression by the combination of nanobubbles and ultrasound (2016)
  • Author(s): Suzuki R, Oda Y, Omata D, Nishiie N, Koshima R, Shiono Y, Sawaguchi Y, Unga J,Naoi T, Negishi Y, Kawakami S, Hashida M, Maruyama K.
  • Journal Title: Cancer Sci. Volume: 107 Issue: 3 Pages: 217-113
  • DOI: 10.1111/cas.12867
  • NAID: 120005829401
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Co-administration of Microbubbles and Drugs in Ultrasound-Assisted Drug Delivery: Comparison with Drug-Carrying Particles. (2016)
  • Author(s): Suzuki R, Klibanov AL.
  • Journal Title: Adv Exp Med Biol. Volume: 880 Pages: 205-220
  • DOI: 10.1007/978-3-319-22536-4_12
  • ISBN: 9783319225357, 9783319225364
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nonviral gene delivery systems by the combination of bubble liposomes and ultrasound (2015)
  • Author(s): Daiki Omata, Yoichi Negishi, Ryo Suzuki, Yusuke Oda, Yoko Endo-Takahashi, Kazuo Maruyama
  • Journal Title: Advances in Genetics Volume: 89 Pages: 25-48
  • DOI: 10.1016/bs.adgen.2014.11.001
  • ISBN: 9780128022726
  • Peer Reviewed
• [Journal Article] Kidney-selective gene transfection using anionic bubble lipopolyplexes with renal ultrasound irradiation in mice (2014)
  • Author(s): Kurosaki T, Kawakami S, Higuchi Y, Suzuki R, Maruyama K, Sasaki H, Yamashita F, Hashida M
  • Journal Title: Nanomedicine Volume: 10 Issue: 8 Pages: 1829-1838
  • DOI: 10.1016/j.nano.2014.06.009
  • Peer Reviewed
• [Presentation] Cancer therapy by the combination of ultrasound mediated hyperthermia and immunotherapy (2015)
  • Author(s): Ryo Suzuki, Yusuke Oda, Daiki Omata, Kazuo Maruyama
  • Organizer: EUFUS2015
  • Place of Presentation: ロンドン
  • Year and Date: 2015-10-15
  • Int'l Joint Research
• [Presentation] Novel strategy for ultrasound diagnostics and therapeutics (2014)
  • Author(s): Ryo Suzuki
  • Organizer: The 6th Asian Congress of Hyperthermic Oncology (ACHO)
  • Place of Presentation: AOSSA(福井県）
  • Year and Date: 2014-09-05
  • Invited
• [Presentation] ナノ気泡を利用した超音波 DDS の開発 (2014)
  • Author(s): 鈴木 亮
  • Organizer: 第３０回日本DDS学会学術集会
  • Place of Presentation: 慶応義塾大学 薬学部
  • Year and Date: 2014-07-30
  • Invited
• [Remarks] 帝京大学薬学部
  • URL: http://www.pharm.teikyo-u.ac.jp/
• [Remarks] 帝京大学薬学部薬物送達学研究室
  • URL: http://www.teikyo-dds-lab.com/
• [Remarks] 帝京大学 薬学部 薬物送達学研究室
  • URL: http://www.teikyo-dds-lab.com/