| Project/Area Number |
26560278
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Saitama Prefectural University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Kanemura Naohiko 埼玉県立大学, 保健医療福祉学部 理学療法学科, 准教授 (20379895)
Kokubun Takanori 埼玉県立大学, 保健医療福祉学部 理学療法学科, 助教 (10616395)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 変形性膝関節症 / メカニカルストレス / 関節制動 / 関節軟骨 / TNF-α / Caspase-3 / 関節不安定性 / 動物モデル / ｍＲＮＡ / ＭＭＰ13 / TIMP-1 / collagen type 2A1 / VCAM-1 / COMP |
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| Outline of Final Research Achievements |
Joint instability, such as abnormalities of mechanical stress, secondary to ACL injury is the most significant risk factors for osteoarthritis (OA).This study aimed to assess whether joint instability of knee following ligament injury is an independent risk factor for osteoarthritis of the knee joint.We hypothesized that providing biomechanical control following ACL injury may result in the inhibition of cartilage degradation in the articular cartilage.
In result, an important contribution of our study was in identifying factors that may delay progression of OA. Joint instability appears to contribute to the progression of articular cartilage degeneration independent of intra-articular conditions, and mechanical factors are independent risk factors for OA. Further studies are required to assess the relationship between the chemical and mechanical responses to injury in the pathogenesis of osteoarthritis.
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