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To elucidate the mechanism of bone and cartilage disease in growth phase

Research Project

Project/Area Number 26560279
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionSaitama Prefectural University

Principal Investigator

Kokubun Takanori  埼玉県立大学, 保健医療福祉学部, 助教 (10616395)

Co-Investigator(Kenkyū-buntansha) KANEMURA NAOHIKO  埼玉県立大学, 保健医療福祉学部, 教授 (20379895)
SHIROGANE SATOSHI  国立障害者リハビリテーションセンター(研究所), 福祉機器臨床評価研究室, 室長 (90404764)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsエンテーシス / メカニカルストレス / モーメント / 成長期骨軟骨疾患 / Enthesis / 筋収縮様式 / 筋腱複合体
Outline of Final Research Achievements

In this study, The group of eccentric contraction with down-hill running indicated an increase of calcified fibrocartilage zone compared to other exercise groups in animal experiment. These results suggested the factors of bone and cartilage disease in growth phase were affected by specificity of mechanical stress not primitive overuse.
From the biomechanical studies, although increasing of the knee moment affected by trunk alignment, muscle activities were not changed in lineary. These results suggested that the inconsistency of mechanical stress and muscle activities related to the mechanism of bone-cartilage disease in growth phase. Our results explained eccentric contraction may induce the inflammation of bone insertion site.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 4 results) Book (1 results)

  • [Journal Article] Effect of changing the joint kinematics of knees with a ruptured anterior cruciate ligament on the molecular biological responses in a spontaneous healing in a rat model2016

    • Author(s)
      Kokubun T, Kanemura N, Murata K, Hideki M, Morita S, Jinno T, Takayanagi K
    • Journal Title

      American Journal of Sports Medicine

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Specific contraction types induce different responses in skeletal muscles and tendons in rats.2016

    • Author(s)
      Motoki Kuroo, Takanori Kokubun, Naohiko Kanemura, Kenji Murata, Kiyomi Takayanagi
    • Organizer
      9th World Congress of the International Society of Physical and Rehabilitation Medicine
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2016-06-19 – 2016-06-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 筋収縮様式の違いによるメカニカルストレスの変化がEnthesis(腱付着部)に及ぼす影響2016

    • Author(s)
      黒尾元基,国分貴徳,村田健児,金村尚彦
    • Organizer
      第51回 日本理学療法学術大会
    • Place of Presentation
      札幌、北海道、日本
    • Year and Date
      2016-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Controlled Abnormal Joint Motion in a Rat Anterior Cruciate Ligament Complete Transection Model Leads to Spontaneous Healing through the Mechanotransduction Mechanism2016

    • Author(s)
      Kokubun T, Kanemura N, Murata K, Hideki M, Morita S, Jinno T, Takayanagi K
    • Organizer
      Orthopaedic Research Society 2016 Annual Meeting
    • Place of Presentation
      Orland, Flirida, United States.
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanotransduction in Anterior Cruciate Ligament Spontaneous Healing2015

    • Author(s)
      Kokubun T, Kanemura N, Murata K, Morita S, Jinno T, Takayanagi K
    • Organizer
      9th World Congress of the ISPRM
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Specific contraction types induce different responses in skeletal muscles and tendons in rats.2015

    • Author(s)
      Kuroo M, Kokubun T, Kanemura N, Murata K, Takayanagi K
    • Organizer
      9th World Congress of the ISPRM
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Controlling the Abnormal Movement Prevent the Progression of Knee Osteoarthritis2015

    • Author(s)
      Mitsui N, Kokubun T, Murata K, Kanemura N, Takayanagi K
    • Organizer
      Osteoarthritis Research Society International 2015 World Congress
    • Place of Presentation
      Seatle, United States
    • Year and Date
      2015-04-30 – 2015-05-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Controlling the Abnormal Movement Prevent the Progression of Knee Osteoarthritis2015

    • Author(s)
      Mitsui N, Kokubun T, Murata K, Kanemura N, Takayanagi K
    • Organizer
      2015 Osteoarthritis Research Society International (OARSI) World Congress
    • Place of Presentation
      Seattle, Washington, United States.
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 異なる筋収縮様式により骨格筋の筋腱複合体に及ぼす影響に違いが生じるか?2014

    • Author(s)
      黒尾元基,国分貴徳,金村尚彦,村田健児,高柳清美
    • Organizer
      第33回 関東甲信越ブロック理学療法学会
    • Place of Presentation
      千葉県千葉市
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Research-status Report
  • [Book] 運動器疾患の病態と理学療法2015

    • Author(s)
      森山 英樹、木藤 伸宏、国分 貴徳 他
    • Total Pages
      304
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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