| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The aim of this study was to investigate whether administration of a herbal medicine prevents immobilization-induced atrophy of slow-twitch and fast-twitch muscles fiber. Twenty-seven 10-week old male F344 rats were divided into three experimental groups: control, immobilized (IM), and immobilized and a herbal medicine administration (IM+HM). IM and IM+HM groups were immobilized both lower extremities by casting-tape for 14 days. As expected, IM group induced significant decreases soleus muscle and plantaris muscle compared with CON group. However a herbal medicine administration significant reversed the weight reduction of soleus muscle compared with IM group. On the other hand, IM+HM group did not reverse the weight reduction of plantaris muscle. This study suggests that administration of a herbal medicine has beneficial effects only on slow-muscle fiber dominant soleus muscle atrophy.
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