| Project/Area Number |
26560288
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagoya Gakuin University |
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Principal Investigator |
HIRANO Takayuki 名古屋学院大学, リハビリテーション学部, 教授 (10440661)
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| Co-Investigator(Kenkyū-buntansha) |
伊東 佑太 名古屋学院大学, リハビリテーション学部, 講師 (30454383)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 筋衛星細胞 / 融合 / 筋収縮 / 理学療法学 / 機械刺激 |
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| Outline of Final Research Achievements |
The exercise training cause facilitating recovery of atrophied muscles and increases the number of myonuclei above normal levels. These increases myonuclei numbers may through fusion of myogenic satellite cells with myofibers, but it is unclear. Therefore, we developed an in vitro model that induces muscle contraction by electrical stimulation to differentiated myotube cells with myogenic satellite cells, and investigated the fusion response of myogenic satellite cells to existing myofibers. As a result, we observed that myogenic satellite cells fusing to existing myotube cells with muscle contraction inducing by the electrical stimulation. This model could contribute to further investigations of mechanisms of fusion response of myogenic satellite cells to existing myofibers.
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