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Vitamin D which is a therapeutic drug of osteoporosis may have antidepressant activity by single administration.

Research Project

Project/Area Number 26560293
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKibi International University

Principal Investigator

Kawaura Akihiko  吉備国際大学, 保健医療福祉学部, 教授 (00177643)

Co-Investigator(Kenkyū-buntansha) KITAMURA Yoshihisa  岡山大学, 医歯(薬)学総合研究科, 准教授 (40423339)
AKIYAMA Jyunichi  吉備国際大学, 保健医療福祉学部, 准教授 (00309600)
MIZUTANI Kasatoshi  吉備国際大学, 保健医療福祉学部, 教授 (30108170)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsビタミンD / 強制水泳試験 / オープンフィールド試験 / 活性型ビタミンD3 / 抗うつ活性 / 活性型ビタミンD3
Outline of Final Research Achievements

We examined the effect of 1α-hydroxyvitamin D3[1α(OH)D3] on forced swimming test in mice. The animals were given intragastric administration of 0.5, 1.0, 2,0 μg/kg of 1α(OH)D3 in MCT through a feeding tube. We gave 1α(OH)D3 orally 24, 3 and 1 hours before a forced swimming test. The total time (seconds) of immobility during this session was recorded and scored for 6 min simultaneously. Intragastric administration of 1 α (OH) D3 of 1.0 μg/kg reduced immobility time in the forced swimming test. We examined a change of the spontaneous momentum in an open field test to prove this reasoning that 1α(OH)D3 is different from analeptica in effects pattern. 1α(OH)D3 at all concentration (0.5, 1.0, 2.0 μg/kg ) had no effect on the locomotor study compared with control. These results suggest that 1α(OH)D3 may have antidepressant-like activity.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2015

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] ラット骨折モデルによる高濃度人工炭酸浴の骨折治癒への影響-TGF-β1の血中濃度変化と組織学的観察による検討2015

    • Author(s)
      秋山純一、高須賀純一、野中紘士、矢田智大、川浦昭彦、中嶋正明、加納良男、畦五月、
    • Journal Title

      吉備国際大学保健福祉研究所研究紀要

      Volume: 16号 Pages: 17-20

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Akt酵素活性に変異を誘導したヒト正常繊維芽細胞の解析2015

    • Author(s)
      加納良男、平上二九三、川浦昭彦、元田弘敏、小池好久、秋山純一、井上茂樹、河村顕
    • Journal Title

      吉備国際大学保健福祉研究所研究紀要

      Volume: 16号 Pages: 17-20

    • NAID

      40020549138

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 入院期心疾患患者における集団反復起立運動の効果について2015

    • Author(s)
      横谷浩士、三浦秀之、岩瀬浩一、関 優、藤本幹雄、原田和弘、川浦昭彦、元田弘敏
    • Journal Title

      日本心臓リハビリテーション学会誌

      Volume: 20 Pages: 222-232

    • NAID

      40021137810

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 介護予防教室を利用する二次予防対象者における、転倒関連因子の改善と糖尿病の影2015

    • Author(s)
      藤田理恵、川浦昭彦、長田美和、古屋あゆみ、山本きよみ、大平禎司、伊藤達賀、浅川智
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      海峡メッセ下関
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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