| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
Fractures due to falls and decreased bone density greatly affect the activities of daily living. In addition, arthritis is a condition that develops with aging, and this condition must be actively prevented and treated. The current study used a new method to apply 2 forms of mechanical stress to a mouse model of decreased bone density and it examined the relief of symptoms due to that stress. Results revealed that bone density actively decreased and bone metabolism actively occurred after menopause. Sufficient rest following mechanical stress presumably led to relief of symptoms of decreased bone density. An experiment involving a mouse model of arthritis also indicated that the level of expression of antiinflammatory myokines by skeletal muscle following mechanical stress increased while the level of expression of inflammatory myokines was limited. This presumably delayed the development and progression of arthritis.
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