| Project/Area Number |
26560354
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition (2015)
National Institute of Health and Nutrition (2014) |
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Principal Investigator |
Yamada Yosuke 国立研究開発法人医薬基盤・健康・栄養研究所, 基礎栄養研究部, 研究員 (60550118)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Yuya 京都学園大学, 研究・連携支援センター, 研究員 (70644376)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | サルコペニア / 老化 / 骨格筋 / 固有筋力 / 生体電気インピーダンス分光法 / 筋細胞膜 / 静電容量 / 筋生理学 |
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| Outline of Final Research Achievements |
Skeletal muscles contain a large volume of water that is classified into intracellular (ICW) and extracellular (ECW) water fractions. Segmental bioelectrical impedance spectroscopy (S-BIS) is a unique tool used to assess the segmental ratio of ECW/ICW in the limbs. We evaluated 405 community-living people. ECW and ICW in the upper legs were assessed by S-BIS. Isometric knee extension strength (KES), gait speed, and skeletal muscle mass (SM) were measured. Thigh ECW/ICW was negatively correlated with KES and gait speed (r = −0.617 and −0.431, respectively, p < 0.001) and increased with age (p < 0.001). Thigh ECW/ICW was a significant predictor of KES and gait speed independent of age, sex, BMI, and SM. Relative expansion of ECW against ICW in the thigh muscles is a factor in decreased muscle quality and a biomarker of muscle aging.
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