Non-invasive assessment of skeletal muscle membrane in human
| Project/Area Number |
26560354
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition (2015)
National Institute of Health and Nutrition (2014) |
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Principal Investigator |
Yamada Yosuke 国立研究開発法人医薬基盤・健康・栄養研究所, 基礎栄養研究部, 研究員 (60550118)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Yuya 京都学園大学, 研究・連携支援センター, 研究員 (70644376)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | サルコペニア / 老化 / 骨格筋 / 固有筋力 / 生体電気インピーダンス分光法 / 筋細胞膜 / 静電容量 / 筋生理学 |
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| Outline of Final Research Achievements |
Skeletal muscles contain a large volume of water that is classified into intracellular (ICW) and extracellular (ECW) water fractions. Segmental bioelectrical impedance spectroscopy (S-BIS) is a unique tool used to assess the segmental ratio of ECW/ICW in the limbs. We evaluated 405 community-living people. ECW and ICW in the upper legs were assessed by S-BIS. Isometric knee extension strength (KES), gait speed, and skeletal muscle mass (SM) were measured. Thigh ECW/ICW was negatively correlated with KES and gait speed (r = −0.617 and −0.431, respectively, p < 0.001) and increased with age (p < 0.001). Thigh ECW/ICW was a significant predictor of KES and gait speed independent of age, sex, BMI, and SM. Relative expansion of ECW against ICW in the thigh muscles is a factor in decreased muscle quality and a biomarker of muscle aging.
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Report
(3 results)
Research Products
(12 results)
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[Presentation] Muscle Function but Not Mass is Correlated with the AM-PAC™ Mobility Score2016
Author(s)
Bjoern Buehring, Ellen Siglinsky, Yosuke Yamada, Diane Krueger, Mahalakshmi Shankaran, Scott Turner, Gregg Czerwieniec, Marc Hellerstein, William Evans, Dale Schoeller, Neil Binkely
Organizer
American Society for Bone and Mineral Research (ASBMR) 2016
Place of Presentation
Atlanta, USA
Year and Date
2016-09-16
Related Report
Int'l Joint Research
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[Presentation] Advancing Muscle Measurement for Sarcopenia Assessment2015
Author(s)
Bjoern Buehring, Ellen Fidler, Yosuke Yamada, Jessie Libber, Diane Krueger, Shubha Shankaran, Gregg Czerwieniec, Chancy Fessler, William Evans, Scott Turner, Marc Hellerstein, Dale Schoeller, Neil Binkley
Organizer
American Society for Bone and Mineral Research (ASBMR) 2015
Place of Presentation
Seattle, USA
Year and Date
2015-10-09
Related Report
Int'l Joint Research
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