Exploration of the visceral organs in response to the sensory afferent signals from skeletal muscles

• Project/Area Number: 26560368
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: Shigakkan University (2015-2016); University of Miyazaki (2014)
• Principal Investigator: Toshinai Koji 至学館大学, 健康科学部, 教授 (80381101)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 感覚神経級進路 / 骨格筋 / 肝臓 / 脳 / エネルギー代謝 / ATP / 糖新生 / 後根神経節 / 感覚神経求心路 / 視床下部弓状核 / 迷走神経遠心路 / ATP受容体 / 感覚神経 / 求心情報伝達 / エネルギー恒常性 / グルコース / マイオカイン / 筋収縮 / 衛星細胞 / 後根神経 / 糖代謝 / 感覚情報伝達

Outline of Final Research Achievements

The skeletal muscle has to keep demanding energy to maintain muscle contraction during exercise. The increasing metabolic demands of the working muscle cannot maintain without glucose supply from the liver or free fatty acids from the adipose tissue. However, It is uncertain how the information of metabolic demands of working muscle was transferred to the other visceral organs. This study suggested that the information of metabolic demands of working muscle, at least in part, is transmitted to the brain through the sensory afferent nerve. In addition, The information may induce the increase of a part of glucogenesis pathway in the liver, as a result of conversion to the activation of vagal efferent system in the brain.

Research Products

• [Journal Article] NERP-2 regulates gastric acid secretion and gastric emptying via the orexin pathway. (2017)
  • Author(s): Cherl Namkoong, Koji Toshinai, Zaved Waise, Hideyuki Sakoda, Kazuki Sasaki, Yoichi Ueta, Min-Seon Kim, Naoto Minamino, Masamitsu Nakazato.
  • Journal Title: Biochem Biophys Res Commun Volume: 485 Issue: 2 Pages: 409-413
  • DOI: 10.1016/j.bbrc.2017.02.064
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Centra insulin-action activates Kupffer cells by suppressing hepatic vagal activation through nicotinic alpha 7 acetylcholine receptor. (2016)
  • Author(s): Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H
  • Journal Title: Cell reports Volume: 14 Issue: 10 Pages: 2362-2374
  • DOI: 10.1016/j.celrep.2016.02.032
  • Peer Reviewed / Open Access
• [Journal Article] Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation (2015)
  • Author(s): Naznin F, Toshinai K, Waise TM, NamKoong C, Md Moin AS, Sakoda H, Nakazato M
  • Journal Title: J Endocrinol Volume: 226 Issue: 1 Pages: 81-92
  • DOI: 10.1530/joe-15-0139
  • Peer Reviewed / Open Access
• [Journal Article] One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice (2015)
  • Author(s): Waise TM, Toshinai K, Naznin F, NamKoong C, Md Moin AS, Sakoda H, Nakazato M
  • Journal Title: Biochem Biophys Res Commun Volume: 464 Issue: 4 Pages: 1157-1162
  • DOI: 10.1016/j.bbrc.2015.07.097
  • Peer Reviewed / Open Access
• [Journal Article] Neuroendocrine regulatory peptide-1 and -2 (NERPs) inhibit the excitability of magnocellular neurosecretory cells in the hypothalamus. (2014)
  • Author(s): Toshinai K, Saito T, Yamaguchi H, Sasaki K, Tsuchimochi W, Minamino N, Ueta Y, Nakazato M
  • Journal Title: Brain Res Volume: 1563 Pages: 52-60
  • DOI: 10.1016/j.brainres.2014.03.038
  • Peer Reviewed / Open Access
• [Journal Article] Circulating Des-acyl Ghrelin Improves Cardiovascular Risk Prediction in Older Hypertensive Patients (2014)
  • Author(s): Yano Y, Nakazato M, Toshinai K, Inokuchi T, Matsuda S, Hidaka T, Hayakawa M, Kangawa K, Shimada K, Kario K
  • Journal Title: Am J Hypertens Volume: 27 Issue: 5 Pages: 723-733
  • DOI: 10.1093/ajh/hpt232
  • Peer Reviewed
• [Presentation] Ghrelin improves age-related and lifestyle diseases (2016)
  • Author(s): Toshiba K, Maize TM, Nannie F, Nakazato M
  • Organizer: Keystone symposia on molecular and cellular biology: Epigenetic and metabolic regulation of aging and aging-related diseases
  • Place of Presentation: サンタフェ、ニューメキシコ州、アメリカ合衆国
  • Year and Date: 2016-05-01
  • Int'l Joint Research
• [Presentation] Ghrelin improves age-related and lifestyle diseases (2016)
  • Author(s): Toshinai K, Waise TM Zaved, Naznin Farhana, Nakazato Masamitsu
  • Organizer: Keystone Symposia on Molecular and Cellular Biology, Epigenetic and Metabolic Regulation of Aging and Aging-Related Diseases
  • Place of Presentation: Santa Fe, NM, USA
  • Year and Date: 2016-05-01
  • Int'l Joint Research
• [Presentation] エネルギー代謝調節における迷走神経の役割 (2016)
  • Author(s): 十枝内厚次
  • Organizer: 第93回日本生理学会
  • Place of Presentation: 札幌
  • Year and Date: 2016-03-22
  • Invited
• [Presentation] The role of the vagal afferent nerve in ghrelin-induced feeding. (2014)
  • Author(s): Toshinai K
  • Organizer: The Conference on Bioactive Peptides for Cell-Cell Communication 2014
  • Place of Presentation: ホテルグランビア京都、京都
  • Year and Date: 2014-09-10 – 2014-09-12
  • Invited
• [Presentation] グレリン/成長ホルモンによる治療の可能性 (2014)
  • Author(s): 十枝内厚次、中里雅光
  • Organizer: 56回日本老年医学会学術集会
  • Place of Presentation: 福岡国際会議場、福岡
  • Year and Date: 2014-06-12 – 2014-06-14
  • Invited
• [Presentation] エネルギー代謝とサルコペニア (2014)
  • Author(s): 十枝内厚次、中里雅光
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡国際会議場、福岡
  • Year and Date: 2014-05-21 – 2014-05-24
  • Invited
• [Presentation] グレリンによる骨格筋抗萎縮治療の可能性 (2014)
  • Author(s): 十枝内厚次、越中敬一、中里雅光
  • Organizer: 第87回日本内分泌学会学術総会会
  • Place of Presentation: 福岡国際会議場、福岡
  • Year and Date: 2014-04-24 – 2014-04-26