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Exploration of the visceral organs in response to the sensory afferent signals from skeletal muscles

Research Project

Project/Area Number 26560368
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionShigakkan University (2015-2016)
University of Miyazaki (2014)

Principal Investigator

Toshinai Koji  至学館大学, 健康科学部, 教授 (80381101)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords感覚神経級進路 / 骨格筋 / 肝臓 / 脳 / エネルギー代謝 / ATP / 糖新生 / 後根神経節 / 感覚神経求心路 / 視床下部弓状核 / 迷走神経遠心路 / ATP受容体 / 感覚神経 / 求心情報伝達 / エネルギー恒常性 / グルコース / マイオカイン / 筋収縮 / 衛星細胞 / 後根神経 / 糖代謝 / 感覚情報伝達
Outline of Final Research Achievements

The skeletal muscle has to keep demanding energy to maintain muscle contraction during exercise. The increasing metabolic demands of the working muscle cannot maintain without glucose supply from the liver or free fatty acids from the adipose tissue. However, It is uncertain how the information of metabolic demands of working muscle was transferred to the other visceral organs. This study suggested that the information of metabolic demands of working muscle, at least in part, is transmitted to the brain through the sensory afferent nerve. In addition, The information may induce the increase of a part of glucogenesis pathway in the liver, as a result of conversion to the activation of vagal efferent system in the brain.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results)

  • [Journal Article] NERP-2 regulates gastric acid secretion and gastric emptying via the orexin pathway.2017

    • Author(s)
      Cherl Namkoong, Koji Toshinai, Zaved Waise, Hideyuki Sakoda, Kazuki Sasaki, Yoichi Ueta, Min-Seon Kim, Naoto Minamino, Masamitsu Nakazato.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 485 Issue: 2 Pages: 409-413

    • DOI

      10.1016/j.bbrc.2017.02.064

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Centra insulin-action activates Kupffer cells by suppressing hepatic vagal activation through nicotinic alpha 7 acetylcholine receptor.2016

    • Author(s)
      Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H
    • Journal Title

      Cell reports

      Volume: 14 Issue: 10 Pages: 2362-2374

    • DOI

      10.1016/j.celrep.2016.02.032

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation2015

    • Author(s)
      Naznin F, Toshinai K, Waise TM, NamKoong C, Md Moin AS, Sakoda H, Nakazato M
    • Journal Title

      J Endocrinol

      Volume: 226 Issue: 1 Pages: 81-92

    • DOI

      10.1530/joe-15-0139

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice2015

    • Author(s)
      Waise TM, Toshinai K, Naznin F, NamKoong C, Md Moin AS, Sakoda H, Nakazato M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 464 Issue: 4 Pages: 1157-1162

    • DOI

      10.1016/j.bbrc.2015.07.097

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuroendocrine regulatory peptide-1 and -2 (NERPs) inhibit the excitability of magnocellular neurosecretory cells in the hypothalamus.2014

    • Author(s)
      Toshinai K, Saito T, Yamaguchi H, Sasaki K, Tsuchimochi W, Minamino N, Ueta Y, Nakazato M
    • Journal Title

      Brain Res

      Volume: 1563 Pages: 52-60

    • DOI

      10.1016/j.brainres.2014.03.038

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating Des-acyl Ghrelin Improves Cardiovascular Risk Prediction in Older Hypertensive Patients2014

    • Author(s)
      Yano Y, Nakazato M, Toshinai K, Inokuchi T, Matsuda S, Hidaka T, Hayakawa M, Kangawa K, Shimada K, Kario K
    • Journal Title

      Am J Hypertens

      Volume: 27 Issue: 5 Pages: 723-733

    • DOI

      10.1093/ajh/hpt232

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Ghrelin improves age-related and lifestyle diseases2016

    • Author(s)
      Toshiba K, Maize TM, Nannie F, Nakazato M
    • Organizer
      Keystone symposia on molecular and cellular biology: Epigenetic and metabolic regulation of aging and aging-related diseases
    • Place of Presentation
      サンタフェ、ニューメキシコ州、アメリカ合衆国
    • Year and Date
      2016-05-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ghrelin improves age-related and lifestyle diseases2016

    • Author(s)
      Toshinai K, Waise TM Zaved, Naznin Farhana, Nakazato Masamitsu
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology, Epigenetic and Metabolic Regulation of Aging and Aging-Related Diseases
    • Place of Presentation
      Santa Fe, NM, USA
    • Year and Date
      2016-05-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] エネルギー代謝調節における迷走神経の役割2016

    • Author(s)
      十枝内厚次
    • Organizer
      第93回日本生理学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] The role of the vagal afferent nerve in ghrelin-induced feeding.2014

    • Author(s)
      Toshinai K
    • Organizer
      The Conference on Bioactive Peptides for Cell-Cell Communication 2014
    • Place of Presentation
      ホテルグランビア京都、京都
    • Year and Date
      2014-09-10 – 2014-09-12
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] グレリン/成長ホルモンによる治療の可能性2014

    • Author(s)
      十枝内厚次、中里雅光
    • Organizer
      56回日本老年医学会学術集会
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2014-06-12 – 2014-06-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] エネルギー代謝とサルコペニア2014

    • Author(s)
      十枝内厚次、中里雅光
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] グレリンによる骨格筋抗萎縮治療の可能性2014

    • Author(s)
      十枝内厚次、越中敬一、中里雅光
    • Organizer
      第87回日本内分泌学会学術総会会
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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