The effect of glycative stress on functions and signal transduction networks in skeletal muscle
Project/Area Number |
26560371
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Sports science
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Research Institution | Toyohashi Sozo University |
Principal Investigator |
EGAWA Tatsuro 豊橋創造大学, 健康科学研究科, 協力研究員 (00722331)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 糖化 / AGEs / 骨格筋 / リン酸化 / タンパク質合成 / タンパク質分解 / 筋形成 / 筋成長 / 筋分化 / 終末糖化産物 / 糖化ストレス / 筋張力 / 逆相タンパク質アレイ / シグナル伝達 |
Outline of Final Research Achievements |
The purpose of this study was to investigate the effect of glycative stress on skeletal muscle functions. The treatment of advanced glycation end products (AGEs) in C2C12 skeletal muscle cells affected phosphorylated state of proteins associated with glucose metabolism and/or muscle development. In addition, the consumption of diets containing high AGEs suppressed skeletal muscle growth via inhibiting muscle development and protein synthesis in mice. These data suggest that glycative stress deteriorates skeletal muscle functions.
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] Heat shock transcription factor 1-associated expression of slow myosin heavy chain in mouse soleus muscle in response to unloading with or without reloading2016
Author(s)
Yokoyama S, Ohno Y, Egawa T, Yasuhara K, Nakai A, Sugiura T, Ohira Y, Yoshioka T, Okita M, Origuchi T, Goto K
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Journal Title
Acta Physiol (Oxf)
Volume: 217
Issue: 4
Pages: 325-337
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Typical responses of nuclear shape and distribution in skeletal muscle fibers in senescence-accelerated mice2015
Author(s)
Goto K, Yokoyama S, Suzuki M, Ikuta A, Ito R, Ikegaya N, Onimura T, Higa M, Egawa T, Ohno Y, Sugiura T, Ohira Y, Yoshioka T
Organizer
International Conference on Biochemistry of Exercise (IBEC 2015)
Place of Presentation
Sao Pulo, Brazil
Year and Date
2015-09-07
Related Report
Int'l Joint Research
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[Presentation] Involvment of AMPK on hindlimb unloading-induced adaptation of muscle mass in mice2015
Author(s)
Egawa T, Goto A, Ohno Y, Yokoyama S, Suzuki-Takuwa M, Ikuta A, Hayashi T, Sugiura T, Ohira Y, Yoshioka T, Goto K
Organizer
The 11th World Congress of the International Society for Adaptive Medicine (ISAM 2015)
Place of Presentation
米子コンベンションセンター(鳥取県米子市)
Year and Date
2015-05-27
Related Report
Int'l Joint Research
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[Presentation] Responses of circulating microRNAs to unloading-associated atrophy and reloading-induced regrowth of mouse hindlimb skeletal muscle2014
Author(s)
Suzuki M, Egawa T, Ikuta A, Goto A, Yokoyama S, Ohno Y, Sugiura T, Ohira Y, Yoshioka T, Goto K
Organizer
2014 Australian Physiological Society (AuPS) Meeting
Place of Presentation
Brisbane, Australia
Year and Date
2014-11-30 – 2014-12-03
Related Report
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