Does skeletal muscle cell-derived adiponectin stimulate glycolipid metabolism?
Project/Area Number |
26560372
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Sports science
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Research Institution | Toyohashi Sozo University |
Principal Investigator |
Goto Katsumasa 豊橋創造大学, 保健医療学部, 教授 (70239961)
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Co-Investigator(Renkei-kenkyūsha) |
OHNO Yoshitaka 豊橋創造大学, 保健医療学部, 講師 (80440808)
YOKOYAMA Shingo 豊橋創造大学, 保健医療学部, 助教 (30706859)
EGAWA Tatsuro 豊橋創造大学, 健康科学研究科, 学振特別研究員(PD) (00722331)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 骨格筋細胞 / 分化 / アディポネクチン / アディポネクチン受容体 / 自己分泌 / 傍分泌 / オートクリン / パラクリン |
Outline of Final Research Achievements |
It is generally accepted that adiponectin is exclusively synthesized in and secrets from adipocyte, and stimulates glycolipid metabolism in skeletal muscle cells via circulating blood. Even though recent studies demonstrate the expression of adiponectin in skeletal muscle cells, there is no report regarding a physiological role of adiponectin that is expressed in skeletal muscle cells. The purpose of this study was to investigate the physiological role(s) of skeletal muscle cell-derived adiponectin in skeletal muscle differentiation. Knockdown of adiponectin and/or adiponectin receptor 1 suppressed myogenic differentiation, in part. Evidences of this study indicated skeletal muscle-derived adiponectin persist or stimulate myogenic differentiation to modulate its size in autocrine or paracrine manner. Skeletal muscle derived adiponectin may regulate glycolipid metabolism in skeletal muscle cells via modulating muscle mass.
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Report
(3 results)
Research Products
(57 results)
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[Journal Article] Involvement of AMPK in regulating slow-twitch muscle atrophy during hindlimb unloading in mice.2015
Author(s)
Egawa T, Goto A, Ohno Y, Yokoyama S, Ikuta A, Suzuki M, Sugiura T, Ohira Y, Yoshioka T, Hayashi T, Goto K.
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Journal Title
Am J Physiol Endocrinol Metab.
Volume: 309
Issue: 7
Pages: E651-E662
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Typical responses of nuclear shape and distribution in skeletal muscle fibers in senescence-accelerated mice2015
Author(s)
Katsumasa Goto, Shingo Yokoyama, Miho Suzuki, Akihiro Ikuta, Rika Ito, Naomi Ikegaya, Tomoko Onimura, Masaki Higa, Ayane Nakamura, Tatsuro Egawa, Yoshitaka Ohno, Takao Sugiura, Yoshinobu Ohira, Toshitada Yoshioka
Organizer
International Conference on Biochemistry of Exercise (IBEC 2015)
Place of Presentation
Sao Paulo (Brazil)
Year and Date
2015-09-07
Related Report
Int'l Joint Research
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[Presentation] Skeletal muscle function and serum thiobarbituric acid reactive substances level are improved by the combination treatment of catechin-ingestion with heat stress in healthy elderly women2014
Author(s)
Toshitada Yoshioka, Hodeshi Oda, Noriyasu Ota, Atsuya Watanabe, Hidefumi Kitazawa, Michihito Igaki, Atsushi Suzuki, Akira Shimotoyodome, Tadashi Hase, Takao Sugiura, Katsumasa Goto
Organizer
43rd European Muscle Conference 2014 (EMC 2014)
Place of Presentation
Salzburg(Austria)
Year and Date
2014-09-10 – 2014-09-14
Related Report
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[Presentation] Essential role of ankle dorsiflexion as the countermeasure for soleus muscles in human subjects2014
Author(s)
Hirooki Okabe, Tomotaka Ohira, Kawano Fuminori, Yoshihiko Oke, Ryo Fujita, Takashi Ohira, Naoya Nakai, Luna Ohira, Katsumasa Goto, Hisashi Naito, Yoshinobu Ohira
Organizer
International Society for Gravitational Physiology 2014
Place of Presentation
Waterloo、Ontario(Canada)
Year and Date
2014-06-15 – 2014-06-20
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