Effects of creatine-analogue treatment on the energy metabolism in skeletal muscles
| Project/Area Number |
26560373
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Doshisha University |
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Principal Investigator |
Ohira Yoshinobu 同志社大学, スポーツ健康科学部, 教授 (50185378)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ラット骨格筋 / クレアチン枯渇 / 炭水化物代謝 / 脂質代謝 / クレアチン含有量 / 筋エネルギー代謝 / 収縮特性 |
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| Outline of Final Research Achievements |
Effects of creatine levels on the contractile and metabolic properties in skeletal muscles were studied in rats. As the results, shift toward slow-twich type was induced by beta-GPA feeding even in soleus, although such trend was prominent in extensor digitorum longus. Further, inhibition of carbohydrate metabolism and simulation of lipid utilization were induced. It was indicated that oxydative capacity of skeletal muscles was increased following chronic depetion of creatine, although daily muscle activities were less, on the contrary. These observations gave important suggestions not only for basic science, but also for the exercise training areas. However, beneficial effects by treatment using creatine were not observed.
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] Speed and/or inclination-dependent mobilization of human leg muscles during walking with a unique exception2015
Author(s)
Ohira, T., H. Okabe, F. Kawano, R. Fujita, T. Ohira, K. Ohira, Y. Oke, N. Nakai, R.R. Roy, V.R. Edgerton, and Y. Ohira
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Journal Title
Acta Astronautica
Volume: 116
Pages: 237-246
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Effects of long time exposure to simulated micro- and hypergravity on skeletal architecture2015
Author(s)
Canciani, B., A. Ruggiu, A. Giuliani, D. Panetta, K. Marozzi, M. Tripodi, P.A. Salvadori, M. Cilli, Y. Ohira, R. Cancedda, and S. Tavella
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Journal Title
J. Mech. Behav. Biomed. Mater.
Volume: 51
Pages: 1-12
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Involvement of AMPK in regulating skeletal muscle atrophy during hindlimb unloading in mice2015
Author(s)
Egawa, T., A. Goto, Y. Ohno, S. Yokoyama, A. Ikuta, M. Suzuki, T. Sugiura, Y. Ohira, T. Yoshioka, T. Hayashi, and K. Goto
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Journal Title
Am. J. Physiol. Endocrinol. Metabol.
Volume: 309
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Estimation of leg-muscle mobilization during walking on the Mars and the Moon using an antigravity treadmill in humans2016
Author(s)
Kamibayashi, K., T. Wakahara, S. Yoshida, N. Tsujiuchi, A. Ito, Y. Nakamura, T. Izawa, Y. Fujisawa, and Y. Ohira
Organizer
2016 International Space Station Research & Development (ISSR&D) Cnference
Place of Presentation
San Diego, U.S.A.
Year and Date
2016-07-12
Related Report
Int'l Joint Research / Invited
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[Presentation] Involvement of AMPK on hindlimb unloading-induced adaptation of muscle mass in mice2015
Author(s)
Egawa, T., A. Goto, Y. Ohno, S. Yokoyama, M. Suzuki-Takuwa, A. Ikuta, T. Hayashi, T. Sugiura, Y. Ohira, T. Yoshioka, and K. Goto.
Organizer
The 11th World Congress of the International Society for Adaptive Medicine
Place of Presentation
Yonago City, Japan
Year and Date
2015-05-27
Related Report
Int'l Joint Research
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